نتایج جستجو برای: hyperlipoproteinemia

تعداد نتایج: 4591  

M MESHKAT, M MOAZENZADEH, S DABIRI, S SHAMSADINI,

In this report, a 10 year old boy with both tendinous and tuberous xanthoma is presented. Premature corneal arcus and aortic stensosis were associated findings in this case. Tuberous and tendinous xanthomas are two clinical varieties of one disease, both of which are seen in type II hyperlipoproteinemia. Increased serum cholesterol with pathological findings of skin lesions with oculocardia...

Journal: :Indian Journal of Dermatology, Venereology, and Leprology 2014

Journal: :The Journal of biological chemistry 1993
A M van den Maagdenberg M H Hofker P J Krimpenfort I de Bruijn B van Vlijmen H van der Boom L M Havekes R R Frants

Apolipoprotein (apo) E3-Leiden, described in a large Dutch family, is associated with a dominantly inherited form of familial dysbetalipoproteinemia. To study the effect of the APOE*3-Leiden mutation in vivo, transgenic mice were generated using a genomic 27-kilobase DNA construct isolated from the APOE*3-Leiden proband. This construct carried the APOE gene, the APOC1 gene, and all known regula...

Journal: :Journal of lipid research 1999
R W Mahley Y Huang S C Rall

Type III hyperlipoproteinemia (HLP) is a genetic disorder characterized by accumulation of remnant lipoproteins in the plasma and development of premature atherosclerosis. Although receptor binding-defective forms of apolipoprotein (apo) E are the common denominator in this disorder, a number of apparent paradoxes concerning its pathogenesis still exist. However, studies in transgenic animals a...

Journal: :Circulation 1978
D H Blankenhorn S H Brooks R H Selzer R Barndt

The rate of change of femoral atherosclerosis has been determined in 25 treated hyperlipoproteinemic patients. There were 13 Type II patients and 12 Type IV patients. Serial angiograms had been performed at an interval averaging 13 months. Film densities were analyzed by digigal image processing to yield a computer estimate of atherosclerosis (CEA). Serial measurements of CEA on each patient we...

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