نتایج جستجو برای: hydroxamic acids
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Seeking compounds preferentially potent and selective for MMP-13, we reported in the preceding Letter on a series of hydroxamic acids with a flexible benzamide tail groups.(1a) Here, we replace the amide moiety with non-hydrolyzable heterocycles in an effort to improve half-life. We identify a hydroxamate tetrazole 4e that spares MMP-1 and -14, shows >400-fold selectivity versus MMP-8 and >600-...
The enzyme of rat liver that can transform /V-hydroxy-/V2-fluorenyIacetamide into a reactive derivative capable of introducing fluorenylamine groups into nucleic acids has been shown to be a sulfhydryl-dependent enzyme with a molecular weight of approximately 28,000. A 30-fold purifi cation of the enzyme from 105,000 x g supernatants of liver has been achieved by precipitation with ammonium sul...
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