that have been identified as a promising target to reverse aberrant epigenetic states associated with cancer via the regulation of acetylation levels in histone. Aberrant histone acetylation has been observed in the development of numerous malignancies, and HDAC inhibitors (HDACIs) are a promising new treatment strategy for malignant disease. The hydroxamic acid trichostatin A (TSA) have been k...

Titanium raw materials are widely used for the synthesis of various functional – sorbents radionuclides and rare earth elements, additives, filler pigments, etc. Since most titanium concentrates imported, in line with import substitution program, production titanite concentrate from apatite-nepheline ores Khibiny deposits is a promising trend supplying national industry materials. The article p...

N-methyl fatty hydroxamic acids (N-MFHAs) is a derivative of acid (FHA), were synthesized from ketapang seed oil (Terminalia catappa L.) with hydroxylamine enzymatically using immobilized lipase (Lipozyme TL IM). N-MFHAs that are still in mixed state triglycerides the oil. This research aims to determine optimum conditions for separation into their single components and percentage composition H...

Suberoylanilide hydroxamic acid (SAHA) is the prototype of a family of hybrid polar compounds that induce growth arrest in transformed cells and show promise for the treatment of cancer. SAHA induces differentiation and/or apoptosis in certain transformed cells in culture and is a potent inhibitor of histone deacetylases. In this study, we examined the effects of SAHA on the growth of human pro...

STAT1 is a transcription factor that plays a crucial role in signaling by interferons (IFNs). In this study we demonstrated that inhibitors of histone deacetylase (HDAC) activity, butyrate, trichostatin A, and suberoylanilide hydroxamic acid, prevented IFNgamma-induced JAK1 activation, STAT1 phosphorylation, its nuclear translocation, and STAT1-dependent gene activation. Furthermore, we showed ...

PURPOSE The purpose of this study was to determine the efficacy of suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor (HDACi), in prevention of excessive wound healing and scar formation in a rabbit model of glaucoma filtration surgery (GFS). METHODS A rabbit model of GFS was used. Rabbits that underwent GFS received balanced salt solution, or SAHA (50 μM), or mitomycin C...

Histone deacetylase inhibitors (HDACi) are compounds that target the epigenome and cause tumor cell-selective apoptosis. A large number of these agents that have different chemical structures and can target multiple HDACs are being testing in clinical trials and vorinostat is now an approved drug for the treatment of cutaneous T-cell lymphoma. Although these agents are showing promise for the t...