Background: Studies on efficacy of various vaccines that prevent or reduce the primary and recurrent HSV-1 infection have demonstrated the importance of cellular immunity for protection against the infection. We previously used DNA vaccination to induce cellular immunity against HSV-1 infection in mice. Objective: The aim of our study was to evaluate the effect of LIGHT, a member of TNF super f...

Background and Aims: Sudden sensorineural hearing loss (SSNHL) is a common disorder diagnosed in otologic and audiologic practices. Its accompanying symptoms include tinnitus, dizziness, and permanent hearing loss affecting negatively the life quality of affected patients. Many viruses have been involved in the occurrence of SSNHL especially Herpes simplex virus (HSV) type I and II. This study ...

Background: The UL31 protein of herpes simplex virus 1 (HSV-1) plays an important role in the HSV-1 replication, however, its pinpoint functions in the life cycle of the virus have yet to be adequately elucidated. Objectives: An antiserum specific for detecting HSV-1 UL31 was prepared as the foundation for future research on the role of UL31 in the course...

Introduction: Herpes Simplex Virus type 1 (HSV-1) is the virus that most often infects oral cavity. HSV-1 in latent phase migrates to trigeminal ganglion after primary infection and can reactivate cause recurrent intraoral herpes (RIH). The recurrence of RIH multifactorial triggered by decreased immunity, fatigue, hypersensitivity, stress, ultraviolet. Case: Three male patients came Oral Diseas...

The effective way to improve the reliability of fuel metering system in an aero-engine is use a high-speed on/off valve (HSV) instead servo as pilot stage valve. However, dynamic performance easily affected by HSV, so novel two-stage with adjustable maximum opening (AMOHSV) proposed which stroke main regulated rod. Firstly, structure and working principle are presented. Then, entire mathematica...

CONTEXT Herpes simplex virus type 2 (HSV-2) is one of the most common sexually transmitted infections in the United States. No prospective study has shown the ability of condoms to reduce transmission of HSV-2. OBJECTIVE To evaluate risk factors for HSV-2 acquisition and efficacy of condoms in prevention of HSV-2 transmission. DESIGN Analysis of data from a randomized, double-blind, placebo...

Cell surface heparan sulfate (HS) serves as an initial receptor for many different viruses, including herpes simplex virus types 1 and 2 (HSV-1 and 2, respectively). Glycoproteins C and B (gC and gB) are the major components of the viral envelope that mediate binding to HS. In this study, purified gB and gC homologous proteins as well as purified HSV-1 and HSV-2 virions were compared for the ab...

Primary genital herpes simplex virus (HSV) infection is commonly associated with systemic symptoms. A systematic evaluation of HSV viremia during primary genital infection has not been performed previously. Plasma samples from adults with a first clinical episode of genital HSV infection were assayed for HSV DNA by polymerase chain reaction. One hundred sixty-four adults had confirmed primary g...

Herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) are seen as close relatives but also unambiguously considered as evolutionary independent units. Here, we sequenced the genomes of 18 HSV-2 isolates characterized by divergent UL30 gene sequences to further elucidate the evolutionary history of this virus. Surprisingly, genome-wide recombination analyses showed that all HSV-2 genomes sequenced to...

Neonatal herpes simplex virus (HSV) infections may be caused by either herpes simplex virus type-1 (HSV-1) or herpes simplex virus type-2 (HSV-2). In the United States, HSV-2 is responsible for 75% of genital and neonatal infections, while HSV-1 causes the rest. HSV-1 more commonly affects the oropharynx, the eyes and the central nervous system.1,2 It is estimated that 20 to 30% of sexually act...