A 47-year-old woman presented with a 1-year history of a nodule on her right palm. She stated that the lesion had originally appeared without any trigger one year previously and that it had gradually increased in size. Physical examination revealed a pedunculated, solitary, asymptomatic nodule, 30 × 30 mm (Fig. 1). The prominent stalk was 8 mm long. The nodule was smooth, skin-coloured and soft...

common ancestor lacked a bacterial protein that would be recognizable as a member of the mitochondrial porin protein family, but had a protein translocase that served to import proteins across the outer mitochondrial membrane. We propose that this protein translocase was of bacterial origin, and had an amino-terminal domain with features common to POTRA domains. In the 'endosymbiont model', ATO...

We report a case of the Werdnig-Hoffmann disease in a 4-month-old male infant. The morphological study revealed perimysial fibrosis, variability in the size of muscle fibers, absence of target fibers, few central nuclei and normality in vessels, nerves and neuromuscular junctions. The morphometrical examination showed the existence of normal-sized and atrophic fibers in both fibrillar types, as...

Why research Raoul Hoffmann and the evolution of external skeletal fixation? [1] As a young surgeon assigned to duty on the Hospital Ship Sanctuary during the Vietnam War, I was flown in and reported to the Commanding Officer. The Captain said my assignment was in Orthopedics. I replied ‘my main interest is in Neurosurgery.’ He said there were no neurosurgeons on the hospital ship so he could s...

The prevalence of Werdnig-Hoffmann disease was found to be 0.66 per 10,000 livebirths in Hungary from 1973 to 1980. However, the true prevalence is estimated to be 1 per 10,000 livebirths, which exceeds the level of a previously published English study. There was no higher fetal death rate in previous and subsequent pregnancies of index patients' mothers. The occurrence in sibs was 32%, probabl...

L'hamartome lipomateux superficiel de Hoffmann-Zurhelle est une tumeur bénigne souvent congénitale. Histologiquement, il est caractérisé par la présence hétérotopique de cellules adipeuses quelquefois lipoblastiques autour des trajets vasculaires dermiques. Nous rapportons une nouvelle observation de forme multiple à révélation tardive chez une femme âgée de 31 ans sans antécédents pathologique...

purpose: oculocardiac reflex (ocr) is a frequent event during strabismus surgery. the aim of this study is to compare the preventive effect of intravenous lidocaine and hyoscine on ocr.methods: this prospective, randomized clinical trial was performed on 75 patients (5-63 years old) underwent strabismus surgery. patients divided randomly into three groups. intravenous hyoscine (0.2 mg/kg), lido...

background: h-reflex is a valuable electrophysiological technique for assessing nerve conduction through entire length of afferent and efferent pathways, especially nerve roots and proximal segments of peripheral nerves. the aim of this study was to investigate the relation between normal values of flexor carpi radialis (fcr) h-reflex latency, upper limb length and age in normal subjects, and t...

Payne conjectured in 1967 that the nodal line of second Dirichlet eigenfunction must touch boundary domain. In their 1997 breakthrough paper, Hoffmann-Ostenhof, Hoffmann-Ostenhof and Nadirashvili proved this to be false by constructing a counterexample plane with many holes raised question minimum number can have. paper we prove it is at most 6.