نتایج جستجو برای: hippocampal ca1

تعداد نتایج: 46398  

Journal: :Science 2006
Jonathan R Whitlock Arnold J Heynen Marshall G Shuler Mark F Bear

Years of intensive investigation have yielded a sophisticated understanding of long-term potentiation (LTP) induced in hippocampal area CA1 by high-frequency stimulation (HFS). These efforts have been motivated by the belief that similar synaptic modifications occur during memory formation, but it has never been shown that learning actually induces LTP in CA1. We found that one-trial inhibitory...

Journal: :Molecular medicine reports 2014
Tianjun Wang Peiyuan Lv Wei Jin Hezhen Zhang Jingfang Lang Mingyue Fan

The aim of this study was to investigate the effects of donepezil hydrochloride (DH) on the expression of the calpain I-cyclin-dependent kinase5/p25 (CDK5/p25) pathway in the hippocampal CA1 region in mice with cerebral ischemia-reperfusion (I/R). Mice were randomly divided and assigned to the sham operation group (SO), the model group (MG) and the DH treatment group (TG). The pathological appe...

Journal: :Brain research 1992
S J Mizumori K E Ward A M Lavoie

Reversible inactivation of the medial septal area results in a spatial memory impairment and selective disruption of hilar/CA3, but not CA1, location-specific discharge. The present study examined the possibility that such septal deafferentation produces effects on hippocampal function by altering physiological properties of the primary input and output structures for hippocampus, the entorhina...

Journal: :The Journal of veterinary medical science 2010
Yukie Saegusa Gye-Hyeong Woo Hitoshi Fujimoto Kaoru Inoue Miwa Takahashi Masao Hirose Katsuhide Igarashi Jun Kanno Kunitoshi Mitsumori Akiyoshi Nishikawa Makoto Shibutani

To determine whether developmental hypothyroidism causes permanent disruption of neuronal development, we first performed a global gene expression profiling study targeting hippocampal CA1 neurons in male rats at the end of maternal exposure to anti-thyroid agents on weaning (postnatal day 20). As a result, genes associated with nervous system development, zinc ion binding, apoptosis and cell a...

Journal: :Acta neurobiologiae experimentalis 2013
Ewa Badowska-Szalewska Beata Ludkiewicz Justyna Sidor-Kaczmarek Grazyna Lietzau Jan H Spodnik Dariusz Świetlik Beata Domaradzka-Pytel Janusz Moryś

It is postulated that stress differentially affects interleukin-1beta (IL-1beta) during ontogenetic life. This study examined the influence of chronic exposure to forced swim (FS) stress or high-light open-field (HL-OF) stress on interleukin-1beta (IL-1beta). The total level of IL-1beta protein was assessed by Western blot analysis of hippocampal extracts. Double immunofluorescence staining was...

Journal: :The Journal of Experimental Medicine 1998
Tong-Chun Wen Junya Tanaka Hui Peng Junzo Desaki Seiji Matsuda Nobuji Maeda Hiroko Fujita Kohji Sato Masahiro Sakanaka

In the central nervous system, interleukin (IL)-3 has been shown to exert a trophic action only on septal cholinergic neurons in vitro and in vivo, but a widespread distribution of IL-3 receptor (IL-3R) in the brain does not conform to such a selective central action of the ligand. Moreover, the mechanism(s) underlying the neurotrophic action of IL-3 has not been elucidated, although an erythro...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
Audrey Mercer Hayley L Trigg Alex M Thomson

The hippocampal cornu ammonis 2 (CA2) region is unique in being the only CA region receiving inputs from the hypothalamic supramammillary nucleus, of importance in modulating hippocampal theta rhythm, and is seizure resistant in temporal lobe epilepsy. CA2 has, however, been little studied, possibly because of its small size and difficulty encountered in defining its borders. To investigate the...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2017
Luis F Lopez-Santiago Yukun Yuan Jacy L Wagnon Jacob M Hull Chad R Frasier Heather A O'Malley Miriam H Meisler Lori L Isom

Patients with early infantile epileptic encephalopathy (EIEE) experience severe seizures and cognitive impairment and are at increased risk for sudden unexpected death in epilepsy (SUDEP). EIEE13 [Online Mendelian Inheritance in Man (OMIM) # 614558] is caused by de novo missense mutations in the voltage-gated sodium channel gene SCN8A Here, we investigated the neuronal phenotype of a mouse mode...

Journal: :مجله علوم اعصاب شفای خاتم 0
fatemeh alipour shefa neuroscience research center, khatam alanbia hospital, tehran, iran. fariba karimzadeh shefa neuroscience research center, khatam alanbia hospital, tehran, iran. gholamreza hasanzadeh department of anatomy, tehran university of medical sciences, tehran, iran.

triazine derivatives are small synthetic peptides with no apparent toxicity and high target specificity in central nervous system. hippocampal tissue is the most vulnerable area in the alzheimer’s disease (ad). the aim of this study was to investigate the neuroprotective effect of triazine in ad induced by intra-cerebro-ventricular (i.c.v.) administration of streptozotocine (stz). male wistar, ...

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