BACKGROUND Chronic hepatitis B is one of the world's major health concerns [corrected]. The etiological agent of this infection is hepatitis B virus (HBV), which can evade the immune system response. Transforming growth factor beta 1 (TGF-β1) can act against HBV by suppressing the viral replication. The TGF-β1 also plays an important role in preventing liver damage in chronically HBV infected p...

Purpose Nijmegen breakage syndrome 1 (NBS1) has a vital role in DNA double-strand break (DSB) repair, functioning as a sensor to identify and repair DNA damage and maintaining genomic stability by participating in the intra-S-phase checkpoint. Polymorphisms of NBS1 have been investigated in multiple cancers with variable results. To our best knowledge, no previous study has focused on the assoc...

BACKGROUND Mutations in the polymerase (P) gene of hepatitis B virus are often associated with drug resistance. The pattern of mutations varies geographically, thus giving rise to genotypes diversity. OBJECTIVES This study was carried out to detect mutations in P gene of hepatitis B virus isolated from Malaysian HBV carriers. MATERIALS AND METHODS A total of 58 sera samples were analyzed by...

Background: Sofosbuvir-Velpatasvir has a high efficacy in adult patients with chronic hepatitis C infection .In this study, we reported treatment outcome drug children and younger adults Pakistani population.
 Objective: To assess the safety of Sofosbuvir-velpatasvir treating HCV-infected young adults. 
 Methods: This Interventional(Clinical trial) was done Hepatitis clinic Jinnah Hos...

objectives thus, the present study aimed to determine if fas and fasl promoter polymorphisms are associated with the clinical outcome of hbv infection. patients and methods dna samples were obtained from the infected individuals including chronic carrier (n = 50), chronic hepatitis (n = 50), cirrhosis (n = 25), naturally recovered (n = 26) and compared with those of their matched healthy contro...

background and objective: although hepatitis b vaccine immunogenicity is high, certain risk factors such as age, tobacco consumption, obesity and genetic background have been associated with low responsiveness to hbv vaccine. we aimed to evaluate the role of occult hepatitis b virus (hbv) infection in non-responder adults to hbv vaccine in a low endemic area for hbv. material and methods : a to...

background: hepatitis b virus (hbv) gene and protein variations are frequently been seen in chronic patients. the aims of study were to determine the genotypes as well as the patterns of variations distribution in chronically-infected patients from the central part of iran. methods: the surface gene was amplified, sequenced and subsequently aligned using international and national iranian datab...

objective(s) the aim of this study was to characterize the hepatitis b virus surface protein genotypes and sequence variations among hepatitis b virus surface antigen (hbsag) positive chronic patients in hormozgan province, south of iran. materials and methods a total of 8 patients enrolled in this study. the surface gene was amplified and directly sequenced. genotypes and nucleotide/amino acid...

The gut microbiota in the hepatitis B virus related acute-on-chronic liver failure (HBV-ACLF) is poorly defined. We aim to uncover characteristics of HBV-ACLF and other HBV associated pathologies. analyzed microbiome patients with or pathologies healthy individuals by 16S rRNA sequencing metagenomic fecal samples. 212 HBV-ACLF, 252 chronic (CHB), 162 HBV-associated cirrhosis (HBV-LC) 877 were r...