Amplification and enhanced expression of the MYCN oncogene are thought to contribute to the development and progression of human neuroblastomas. Here, we have transfected human neuroblastoma cells that harbor a single MYCN gene copy with the human MYCN gene driven by a viral enhancer/promoter, and we have compared the properties of the parental and the transfected cells. The transfected cells s...

Here we investigate the kinetics of water-assisted CVD (henceforth denoted as supergrowth CVD) by a quantitative time-evolution analysis based on a simple growth model. We found that the supergrowth can be well described by a model where the dynamics of the catalyst activity is treated similar to radioactive decay. An in-depth analysis based on this growth model revealed the kinetics of the sup...

During development, in the central nervous system (CNS), oligodendrocyte progenitor cells (OPCs) migrate to axons and eventually become mature oligodendrocytes. Mature oligodendrocytes wrap around axons and produce myelin sheaths, which insulate the axons. Growth factors, specifically platelet derived growth factor (PDGF) and fibroblast growth factor (FGF), are released in the development of OP...

SL3-3 is a highly T-lymphomagenic murine retrovirus in which the transcriptional enhancer is a major oncogenic determinant. Here, we describe an SL3-3 enhancer variant that induced T-cell lymphomas in all inoculated mice with a shorter latency period than wild-type SL3-3. The enhancer repeat region of this variant contains two deletions encompassing the nuclear factor 1 binding sites in additio...

We studied the mechanism by which an insulator interrupts enhancer signaling to a gene using stably replicated chromatin templates containing the human beta-globin locus control region HS2 enhancer and a target globin gene. The chicken beta-globin 5' HS4 (cHS4) insulator acted as a positional enhancer blocker, inhibiting promoter remodeling and transcription activation only when placed between ...

The purpose of this research was to assess the efficiency monosodium glutamate (MSG) as growth promoter in broiler chicken production. study evaluated effect varying concentrations MSG drinking water chickens on their performance, carcass characteristics and caecal Escherichia coli population. Ninety (90) chicks at 21 days age were randomly selected assigned 5 treatment groups (0g/L, 2g/L, 3g/L...