Progressive granuloma formation is a hallmark of chronic mycobacterial infection. Granulomas are localized, protective inflammatory reactions initiated by CD4+ T cells, which contribute to control of bacterial growth and blockade of bacterial dissemination. In order to understand the costimulatory requirements that allow CD4+ T cells to directly or indirectly induce granulomas, we studied granu...

Granulomatous inflammatory lesions in murine schistosomiasis mansoni undergo a spontaneous diminution at the chronic phase of the disease concurrent with an increase in angiotensin I-converting enzyme (ACE) activity. The objective of this investigation was to determine whether T cells influence ACE activity within the granulomas. Cyclophosphamide and cimetidine treatments of mice, which augment...

An association between granuloma inguinale and genital carcinomas has long been suspected (McKay and Bunch, 1952; Alexander and Shields, 1953; Saltzstein, Woodruff, and Novak, 1956) for the following reasons: (1) The higher incidence of genital carcinomas in areas where granuloma inguinale is endemic, as compared to areas in which granuloma inguinale is not found to any appreciable extent. (2) ...

The granuloma is an elaborated aggregate of immune cells found in non-infectious as well as infectious diseases. It is a hallmark of tuberculosis (TB). Predominantly thought as a host-driven strategy to constrain the bacilli and prevent dissemination, recent discoveries indicate the granuloma can also be modulated into an efficient tool to promote microbial pathogenesis. The aim of future studi...

Pyogenic granuloma is defined as a benign neoplasm of vascular phenotype. This case describes the clinical and histopathological features of a gigantic mucogingival pyogenic granuloma, in a 14-year-old healthy black boy. This exophytic gray-purple mass, related to a toothpick injury, had more than twelve-month evolution on the anterior mandible involving lingual area besides to the floor of the...

Eosinophilic granuloma of the jaw is rare and preferably located within the posterior mandible. In this study, we report a case of multiple eosinophilic granuloma of the jaw in a 22-year-old man. This patient consulted to our hospital due to left-posterior maxilla pain that lasted for one year. X-ray and CT scan revealed an osteolytic area in the left-posterior maxilla. Then, the lesion was res...

In the present study, the distribution of eosinophils at different stages of the formation of hepatic granuloma in mice infected with Schistosoma mansoni was evaluated. From the results obtained, we suggest a new classification for the evolution of hepatic granuloma in mice, constructed from the phases described by other authors. In each phase, there is a different pattern of eosinophil distrib...

Mast cells (MCs) are large granular mononuclear cells which are bone marrow derived, they are found in different tissues and also they can move. Degranulation of MCs is caused by various stimulus .Oral pyogenic granuloma is a recognized oral lesion that possibly originate as a response of tissue, it is suggested that local factors can activate MCs resulting in mediators releases that finally br...

IMPORTANCE Contact granuloma is a difficult-to-treat laryngeal disorder associated with vocal abuse, habitual throat clearing, and laryngopharyngeal reflux. It has a high propensity for persistence and recurrence despite many treatment alternatives. OBJECTIVE To present our experience with recurrent contact granuloma treated with microlaryngoscopic excision and botulinum toxin injection. DE...