Epigenetic gene silencing by aberrant DNA methylation of gene promoter regions is a nonmutagenic but heritable epigenetic mechanism that may mistakenly cause the silencing of important cancer-related tumor suppressor genes. Using a transgenic, V79-derived, mammalian cell line (G12) that contains a bacterial gpt reporter gene in its DNA, we can study carcinogen-induced gene inactivation by mutag...

Cryptosystems based on codes in the rank metric were introduced in 1991 by Gabidulin, Paramanov, and Tretjakov (GPT) and have been studied as a promising alternative to cryptosystems based on codes in the Hamming metric. In particular, it was observed that the combinatorial solution for solving the rank analogy of the syndrome decoding problem appears significantly harder. Early proposals were ...

In previous studies in vitro we showed that the quinone fraction (QF) from the heartwood of Auxemma oncocalyx TAUB. presented antiplatelet and antioxidant activities. In the present work, the QF antioxidant property was evaluated in models of CCl(4)-induced hepatotoxicity in rats, and prolongation of pentobarbital-induced sleeping time in mice. Our results showed that levels of plasma glutamate...

Abstract Despite significant advancements in geomodelling technologies, Accurately estimating hydraulic fracture half-length remains a challenging task. This paper introduces detailed estimation approach using the Gaussian Pressure Transient (GPT) method, which is relatively new. The GPT method iterative, ensuring fast convergence and providing reliable estimations of b’ased on predetermined di...

GPT public key cryptosystem was proposed by Gabidulin, Paramonov and Tretjakov in 1991. This cryptosystem is based on rank error correcting codes. The main advantage of using rank codes in cryptography is that, it has smaller key size as compared to other code based public key cryptosystems. Several attacks against this system were published and some modifications were also proposed withstandin...

In the present study, a series of five members heterocyclic where synthesized by the reaction between isoniazid and various substituted isothiocyanates. The newly synthesized compounds where characterized by IR and 1H-NMR spectral data. The effect of Thiadiazole derivative (2b) in monocyte and Lymphocyte in the differential count is 20349 and 11415 cells/cu.mm, respectively. Prepared compounds ...

The paper presents one of the most interesting Collaborative Networked Organizations in Italy, namely Gruppo Poligrafico Tiberino (GPT), the first adopting the governance model with the Virtual Development Office (VDO) structure. The network is constituted by 21 companies belonging to the paper converting, packaging and logistics sectors. The nature of the collaboration is based on a long term ...

A 50 years-old female was presented to our attention complained for a 3 weeks recurrent chilling fever accompanied, productive cough and dyspnea. An initial laboratory evaluation showed a C-reactive protein (CRP) level of 183 mg/L [reference value (rv) < 5 mg/L], hemoglobin (Hb) level 97 g/L, glutamic oxaloacetic transaminase (GOT) and glutamic-pyruvic transaminase (GPT) respectively of 39 and ...

Monosomic mammalian cell lines would be ideal for studying gene dosage effects, including gene imprinting, and for systematic isolation of recessive somatic mutants parallel to the invaluable mutants derived from haploid yeast. But autosomal monosomies are lethal in early development; although monosomies appear in tumors, deriving cell lines from these tumors is difficult and cannot provide sev...

Developments in nanotechnology are poised to have a pervasive effect on various industries for years to come and nanotechnology management research is beginning to appear in peerreviewed management journals. Much of the research on this early, emergent technology is focused on issues of definition and identification of technology type. In this study, we searched the US Patents and Trademarks Of...