Paroxysmal nocturnal hemoglobinuria (PNH) is caused by phosphatidylinositol glycan-class A (PIG-A) mutations in hematopoietic stem cells (HSCs). PIG-A mutations have been found in granulocytes from most healthy individuals, suggesting that these spontaneous PIG-A mutations are important in the pathogenesis of PNH. It remains unclear if these PIG-A mutations have relevance to those found in PNH....

The domesticated guinea pig, Cavia porcellus (Hystricomorpha, Rodentia), is an important laboratory species and a model for a number of human diseases. Nevertheless, genomic tools for this species are lacking; even its karyotype is poorly characterized. The guinea pig belongs to Hystricomorpha, a widespread and important group of rodents; so far the chromosomes of guinea pigs have not been comp...

This paper documents the application of the Poisson Inverse Gaussian (PIG) regression model for modeling motor vehicle crash data. The PIG distribution, which mixes the Poisson distribution and Inverse Gaussian distribution, has the potential for modeling highly dispersed count data due to the flexibility of Inverse Gaussian distribution. The objectives of this paper were to evaluate the applic...

1. The rate of utilization (k) of labelled thyroxine increased when energy intake, given as standard pig meal, was doubled from 20 to 40 g/kg body-weight per d. When the bulk of food was increased, but not its energy content, the value of k did not change. Ambient temperature was constant throughout the experiment. 2. Groups of pigs were given pig meal at 20 g/kg body-weight, 40 g/kg body-weigh...

Total weaning weight is a function of pig quantity and quality. Pig quality can be associated with individual pig weights and survivability. As litter size increases, total weaning weight increases at a decreasing rate. As shown in Figure 1., larger litter sizes not only wean more weight, but also have higher preweaning mortality. Increased litter size has been associated with smaller, more fra...

Feed is the greatest single cost factor in pig production. In pig diets, energy accounts for the largest proportion of the cost. Therefore, it is critically important that the energy content of a diet is characterized in the best possible way. There are several systems available for the characterization of dietary energy. The most common ones digestible and metabolizable energy describe the ene...

Many Turkish people migrated to Germany between 1955 and 1975. This study was carried out in Göttingen, Germany. Fifty Turkish people (described as patients) were asked about the care they had received from German health care personnel, and 50 German nurses and 50 German physiotherapists were questioned about care they had given to Turkish patients. Significant findings were the needs of the Tu...

This document is based on lectures given at the 2007 NATO Advanced Study Institute on ‘Higher-Dimensional Geometry over Finite Fields’, organized at the University of Göttingen by Yuri Tschinkel, and on lectures given at the 2010 summer school ‘Arithmetic Aspects of Rational Curves’, organized at the Institut Fourier in Grenoble by Emmanuel Peyre. This work is supported in part by National Scie...

THE discovery of America placed the European nations in contact with three major civilizations, the Aztec in the Mexican plateau, the Maya in the Yucatan peninsula, and the Inca in the Peruvian Andes. The Mayas had been settled for centuries in the same area and developed a civilization with high cultural manifestations, whereas the Aztecs and Incas, in spite of their political power and strong...