mesenchymal stem cells (mscs),as the major stem cells for cell therapy, have been studied from different aspects in pre-clinical and clinical settings for more than a decade. these cells modulate the immune system (humoral and cellular immune responses) in vitro by producing soluble factors (anti-inflammatory molecules) and/or making cell-cell contacts. hence they could be used in regenerative ...

hydroxymethylglutaryl co-enzyme a reductase inhibitors, also known as statins, are a class of anti-hyperlipidemic agents. these drugs have been employed vastly to reduce the morbidity and mortality of cardiovascular disorders. soon after their introduction, benefits other than their primary actions were discovered. along with these pleiotropic properties, a series of mainly favorable effects ha...

background: this study explored the state of hematopoietic stem cell transplantation (hsct) recipient patients and problems experienced by them and nurse about these state and problems, in iran. methods: qualitative content analysis was used for analyzing semi-structured interviews with 12 hsct recipient patients and 18 nurses. results: three main categories described the hsct state and problem...

hematopoietic stem cell transplantation (hsct) has been practiced for more than 30 years. hematological malignanciesare the main indications for this treatment. however, its indications in adults are different from children.advances in chemotherapy and target therapy have improved treatment outcome of some of the very high riskcancers, and changed indications of hsct in children. multi-center c...

background: early clinical investigations indicate that an infusion of autologous bone-marrow cells into the infarct-related coronary artery is feasible after acute myocardial infarction. there is increasing evidence that cell transplantation may improve the perfusion and contractile function of the ischemic myocardium . the present study reports primarily the safety of intracoronary bone marro...

introduction: neuroblastoma is the most common extracranial solid tumor in children, accounting for 8% to 10% of all childhood cancers. significantly, autologous transplantation appeared to have the largest impact on survival for the high risk subset of patients, such as those with n-myc amplified metastatic disease diagnosed after age 2 years. patients and methods: this study includes high ris...

peripheral blood stem cell transplantation (pbsct) is an effective treatment for hematological malignancies. mobilization of peripheral blood progenitor cells performs in different ways among transplantation centers. forceful mobilization schedules are comprised of growth factor alone, chemotherapy along with growth factor and also, a newly combination of novel agent such as plerixafor with any...

hematopoietic stem/progenitor cells (hspcs) which give rise to different blood cell types are present within the bone marrow microenvironment, especially in flat bones such as skull, vertebrae, pelvis and chest. interacting factors such as stromal derived factor-1/cxcr4, very late antigen-4/vascular cell adhesion molecule-1, lymphocyte function-associated antigen-1/ intercellular adhesion molec...

background: recently, stem cells have been considered for the treatment of heart diseases, but no marked improvement has been recorded. this is the first study to examine the functional and histological effects of the transplantation of human amniotic mesenchymal stromal cells (hamscs) in rats with heart failure (hf). methods: this study was conducted in the years 2014 and 2015. 35 male wistar ...