نتایج جستجو برای: formaldehyde induced liver injury

تعداد نتایج: 1460942  

Journal: :Scientia pharmaceutica 2015
Reza Heidari Akram Jamshidzadeh Nahid Keshavarz Negar Azarpira

Methimazole is the most widely prescribed antithyroid medication in humans. However, hepatotoxicity is a deleterious adverse effect associated with methimazole administration. No specific protective agent has been developed against this complication yet. This study was designed to investigate the role of taurine as a hepatoprotective agent against methimazole-induced liver injury in mice. Diffe...

2015
Fang-Jie Sun Jun-Feng Jia

Objective: To study the protective effect of polyprenols on acute liver injury induced by CCl4 and D-Gal. Method: The acute liver injury model induced by 0.5% CCl4 in olive oil (10ml/kg) and D-Gal (800mg/kg, i.p.) in mice and rats respectively. 10, 40 and 160 mg/kg polyprenols was administered i.g., to study the protective effect for different doses of polyprenols, the therapeutic effect of eac...

2015
T. Hendrikx M. Malagó R. Shiri-Sverdlov S. W. M. Olde Damink

Background: Liver surgery requires mobilization of the liver resulting in injury. Mobilization is the predominant cause of hepatocyte damage during liver surgery and jeopardizes post-operative liver function. Previously, mobilization-induced liver injury was found to be associated with inflammation. So far, anti-inflammatory drugs to potentially prevent liver inflammation following liver mobili...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2014
Xiaomei Fan Pan Chen Huasen Tan Hang Zeng Yiming Jiang Ying Wang Yongtao Wang Xiangyu Hou Huichang Bi Min Huang

UNLABELLED Acetaminophen (APAP) overdose is the leading cause of drug-induced liver injury. Compensatory liver regeneration is crucial for the final outcome of toxicant-induced injury. However, the molecular mechanisms underlying compensatory liver regeneration in mice after APAP-induced liver injury are not completely understood. This study aimed to investigate the role of dynamic and coordina...

2017
Amara G Nandikolla Olga Derman Deborah Nautsch Qiang Liu Hatef Massoumi Sangeetha Venugopal Ira Braunschweig Murali Janakiram

Ibrutinib, an inhibitor of the Bruton's tyrosine kinase of the B-cell receptor pathway, is an effective therapeutic agent for B-cell lymphomas. As these drugs are novel, long-term or rare adverse events are not yet known. We report the first case of ibrutinib-induced severe liver injury in a patient with relapsed/refractory CLL.

2014
Janese Laster Rohit Satoskar

Aspirin is thought to be a relatively safe drug in adults. The association of aspirin and Reye syndrome in children is well documented. We report a 41-year-old female with pericarditis who was treated with high-dose aspirin and developed subsequent acute liver injury. After discontinuation of aspirin, liver enzyme elevation and right upper quadrant pain both resolved. We conclude that high-dose...

Objective: Liver fibrosis is the primary sign of chronic liver injury induced by various causes. Thymoquinone (TQ) is the major ingredient of Nigella sativa with several beneficial effects on the body. In the present study, we aimed to investigate the effect of TQ on liver fibrosis in a lipopolysaccharide (LPS)-induced inflammation in male rats. Materials and methods: Fifty male Wistar rats wer...

2012
Veronica L. Massey Gavin E. Arteel

Alcohol consumption is customary in most cultures and alcohol abuse is common worldwide. For example, more than 50% of Americans consume alcohol, with an estimated 23.1% of Americans participating in heavy and/or binge drinking at least once a month. A safe and effective therapy for alcoholic liver disease (ALD) in humans is still elusive, despite significant advances in our understanding of ho...

Journal: :Hepatology 2006
Bofeng Li Rui Sun Haiming Wei Bin Gao Zhigang Tian

Administration of concanavalin A (Con A) induces a rapid and severe liver injury in mice. Natural killer T (NKT) cells are recognized to be the key effector cells, and a variety of cytokines [e.g., interleukin 4 (IL-4), IL-5, interferon gamma (IFN-gamma), and tumor necrosis factor alpha (TNF-alpha)] have been shown to play vital roles in Con A-induced liver injury, whereas the role of IL-15, a ...

Journal: :The American journal of psychiatry 2014
Cosmin Sebastian Voican Emmanuelle Corruble Sylvie Naveau Gabriel Perlemuter

OBJECTIVE Antidepressant drugs can cause drug-induced liver injury (DILI). The authors review clinical data relevant to antidepressant-induced liver injury and provide recommendations for clinical practice. METHOD A PubMed search was conducted for publications from 1965 onward related to antidepressant-induced liver injury. The search terms were "liver injury," "liver failure," "DILI," "hepat...

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