BACKGROUND Elevated concentrations of homocysteine and low concentrations of folate may lead to a proinflammatory state that could explain their relation to vascular disease risk. We investigated the effect of lowering homocysteine concentrations by means of folic acid supplementation on markers of inflammation. METHODS In a double-blind, randomized, placebo-controlled trial among 530 men and...

malabsorption could be a risk factor in the development of these diseases. Because bacterial metabolism alters folic acid status and intestinal bacterial colonization is altered by nutritional factors and carbohydrate malabsorption syndromes, dietary measurements should not rely solely on folic acid supplementation but should also consider carbohydrate malabsorption syndromes, especially fructo...

This paper focuses on the current best-evidence-based clinical practices and controversies surrounding folic acid supplementation/fortification for the prevention of neural tube defects (NTDs) during early pregnancy. The paper also discusses the controversies surrounding the effect of folic acid on the prevention as well as the promotion of cancer. Sufficient data is available to safely conclud...

BACKGROUND Remethylation of homocysteine to methionine can occur through either the folate-dependent methionine synthase pathway or the betaine-dependent betaine-homocysteine methyltransferase pathway. The relevance of betaine as a determinant of fasting total homocysteine (tHcy) is not known, nor is it known how the 2 remethylation pathways are interrelated. OBJECTIVE The objectives of the s...

OBJECTIVES Our earlier studies have highlighted that an altered one carbon metabolism (vitamin B12, folic acid, and docosahexaenoic acid) is associated with preeclampsia. Preeclampsia is also known to be associated with oxidative stress and inflammation. The current study examines whether maternal folic acid, vitamin B12 and omega-3 fatty acid supplementation given either individually or in com...

OBJECTIVE To provide information regarding the use of folic acid for the prevention of neural tube defects (NTDs) and other congenital anomalies, in order that physicians, midwives, nurses, and other health-care workers can assist in the education of women in the preconception phase of their health care. OPTION: Folic acid supplementation is problematic, since 50% of pregnancies are unplanned a...

Background: Iron-folic acid deficiency is the most common complication during pregnancy. Iron responsible for various health complications among pregnant women. Compliance with IFA supplementation variable across India several factors are associated compliance supplementation. Objective: The objective of this systematic review to assess affecting toward oral iron-folic women in India. Methods: ...

The present study was conducted to investigate the effect of maternal folic acid supplementation and intrauterine growth retardation (IUGR) on epigenetic modification of hepatic gene expression and lipid metabolism in weanling piglets. Thirty-two primiparous sows were randomly divided into two dietary groups: control group (C, 1.3 mg/kg folic acid) and folic acid supplemented group (FS, 30 mg/k...

Knowledge about the impact of maternal food andmicronutrient supplementation on infant micronutrient status is limited. We examined the effect of maternal food and micronutrient supplementation on infant micronutrient status in the Maternal and Infant Nutrition Interventions in Matlab Trial. Pregnant women (n = 4436) were randomized to Early or Usual promotion of enrollment in a food supplement...

BACKGROUND To assess socioeconomic inequality in periconceptional folic acid supplementation in China. METHODS We used data of periconceptional folic acid (FA) supplementation of rural Chinese women from the National Free Preconception Health Examination Project from 2010 to 2012 and socioeconomic level data from the National Bureau of Statistics. We used logistic models to assess the associa...