BACKGROUND AND OBJECTIVES Wilms tumor-suppressor gene-1 (WT1) plays a key role in kidney development and function. WT1 mutations usually occur in exons 8 and 9 and are associated with Denys-Drash, or in intron 9 and are associated with Frasier syndrome. However, overlapping clinical and molecular features have been reported. Few familial cases have been described, with intrafamilial variability...

OBJECTIVE: To find out the pattern of glomerulopathies in paediatric population, undergoing renal biopsy at Khyber Teaching Hospital, Peshawar. METHODS: This was a prospective study carried out at the department of Nephrology at Khyber Teaching Hospital, Peshawar from June 2010 till June 2012. Ultrasound guided percutaneous renal biopsies were carried out in patients with the finding of; 1) Nep...