the aim of the present study is to evaluate the effect of ethanolic extract of leaves of leptadenia reticulata leaves (lelr) against dalton’s ascitic lymphoma (dal) in swiss albino mice. dal cells were injected intraperitoneally (106 cells/mouse) to the mice. two days after cells injection the animals were treated with 200 mg/kg of lelr for 8 days. five-fluorouracil (20 mg/kg) was used as refer...

INTRODUCTION The pathogenesis of circumscribed palmar hypokeratosis (CPH) is still controversial, and to date there is no treatment of choice. METHODS We report on a patient with CPH responding to treatment with fluorouracil cream. RESULTS The clinical course and histopathological features in our observation point towards the possibility of an underlying squamous cell carcinoma in situ pres...

ADVICE: following a full submission fluorouracil 0.5% / salicylic acid 10% cutaneous solution (Actikerall®) is accepted for use within NHS Scotland. Indication under review: the topical treatment of slightly palpable and/or moderately thick hyperkeratotic actinic keratosis (grade I/II) in immunocompetent adult patients. Fluorouracil 0.5% / salicylic acid 10% cutaneous solution was superior to a...

The effects of cycloheximide and 5-fluorouracil on the formation of low-molecular-weight ribonucleic acid (RNA) in yeast were investigated. Both compounds were found to affect the synthesis of low-molecular-weight RNA of ribosomal origin more than transfer RNA but less than the high-molecular-weight ribosomal RNA. 5-Fluorouracil-containing transfer RNA was separated from normal transfer RNA by ...

1 Casas J A, Subauste C P, Alarc6n G S. A new promising treatment in systemic sclerosis: 5-fluorouracil. Ann Rheum Dis 1987; 46: 763-7. 2 Calabresi P, Parks R E Jr. Chemotherapy of neoplastic diseases. In: Gilman A G, Goodman L S, Rall T W, Murad F, eds. Goodman and Gilman's the pharmacological basis of therapeutics. 7th ed. New York: Macmillan, 1985: 1240-306. 3 Physicians' Desk Reference (PDR...

As one of the initial steps towards the determi nation of the metabolism and mechanism of action of fluorinated pyrimidines, 5-fluorouracil and 5fluoroorotic acid were labeled with radiocarbon in the 2-carbon atom. We have previously reported briefly that fluorouracil is incorporated, as such, into the combined nucleic acids of mouse liver, spleen, and Ehrlich ascites cells (9). The present rep...

Prior to their use in patients with hepatic metastasis of colon cancer, we studied the cell-killing effects of 5-fluorouracil, 5-fluoro-2'-deoxyuridine, 3',5'-dichloromethotrexate (DCM), and 5-fluoro-2'-deoxyuridine, 3',5'-dichloromethotrexate (DCM), and combinations of these fluoropyrimidines with DCM on a human colon carcinoma cell line (HCT-8). Sequential exposure of these cells to DCM follo...

The effect of sequential methotrexate and 5-fluorouracil on the clonal growth of the human colon adenocarcinoma cell, HCT-8, and the hormone-dependent human breast carcinoma cell, 47-DN, was examined. In both cell lines, when 5-fluorouracil was given during the last 6 h of a 24 h methotrexate exposure period, there was marked synergistic inhibition of clonal growth. Shorter intervals or the rev...

Gastrointestinal malignancy may spread to peritoneal surfaces in the absence of lymphatic or hematogenous metastases. To treat peritoneal carcinomatosis, a uniformly lethal disease process, extensive cytoreductive surgery and i.p. chemotherapy were combined. Early postoperative i.p. chemotherapy was instilled in the first few days after the surgical procedure in an attempt to treat anatomic sit...

Recent studies have demonstrated that systemic Corynebacterium parvum increases serum granulocyte-macrophage colony-stimulating factor and stimulates the proliferation of granulocyte-macrophage progenitor cells. It was hypothesized that more rapid cycling of granulocyte-macrophage progenitor cells would render the cells more sensitive to a cell cycle-specific chemotherapeutic agent. The colony-...