Here, we report a case of Cowden syndrome with an unusual clinical course of late-onset oral papillomatosis and a novel germline PTEN mutation. Cowden syndrome is the most common phosphatase and tensin homolog hamartomatous tumor syndrome. It is characterized by multiple hamartomas in the gastrointestinal tract and mucocutaneous lesions such as trichilemmomas, oral papillomatosis, facial papule...

The case of a 27-year-old male with recurrent respiratory papillomatosis including lung involvement is presented. Laryngotracheal papillomatosis with lung involvement is a rare entity associated with human papillomavirus infection. Computed tomography (CT) was essential in guiding diagnostic and therapeutic approaches. Knowledge about the findings of this disease is needed for correct diagnosis...

Juvenile papillomatosis of the larynx and trachea is a rare but well recognised condition, classically developing between the ages of 5 and 15 years but occasionally occurring in infancy. The tumours tend to recur before puberty but rarely do so afterwards. Malignant transformation is said not to complicate this condition.' This report describes a case of squamous carcinoma arising in a patient...

UNLABELLED The association of juvenile papillomatosis with carcinoma is proven, but very rare, as there exist several reported cases. CASE REPORT A 15-year-old girl with no family history of breast cancer presented with two masses in the left breast. The excisional biopsy on both lumps revealed juvenile fibroadenoma and juvenile papillomatosis epithelial proliferation multiple cystic expanded...

Nine children with respiratory papillomatosis have been treated with adenine arabinoside with limited success. No long term benefit was obtained in six, and although resolution was achieved in one and probably two others, this could not be attributed confidently to treatment.

OBJECTIVES To quantify the prevalence of dysplasia and to evaluate the impact of use of cidofovir in recurrent respiratory papilloma biopsy specimens obtained from a pediatric population. DESIGN Retrospective review of patient medical records and histopathologic test results from January 1, 1998, through December 31, 2008. SETTING Children's Hospital of Wisconsin. PATIENTS Patients with a...

INTRODUCTION Recurrent respiratory papillomatosis (RPP) is a rare benign neoplasm caused by human papillomavirus (HPV). RPP is characterized by recurrent proliferation of the papillomata in the respiratory tract. OBJECTIVES AND METHODS Retrospective analysis of all adult patients with diagnosis of recurrent respiratory papillomatosis admitted to our endoscopic unit between 2000 and 2013 with ...