BACKGROUND Prostacyclin analogs are potent vasodilators and possess anti-inflammatory properties. However, the effect of prostacyclin on extracellular matrix (ECM) in COPD is not well known. Collagen fibrils and proteoglycans are essential ECM components in the lung and fibroblasts are key players in regulating the homeostasis of ECM proteins. The aim was to study the synthesis of prostacyclin ...

UNLABELLED Cancer-associated fibroblasts (CAF) are a major constituent of the tumor stroma, but little is known about how cancer cells transform normal fibroblasts into CAFs. microRNAs (miRNA) are small noncoding RNA molecules that negatively regulate gene expression at a posttranscriptional level. Although it is clearly established that miRNAs are deregulated in human cancers, it is not known ...

Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal lung disease, and fibroblasts derived from patients with IPF are resistant to type I collagen matrix-induced cell death. The alteration of the PTEN-Akt axis permits IPF fibroblasts to maintain a pathological phenotype on collagen by suppressing autophagy. However, the precise underlying mechanism by which the Akt downstream molecule sup...

Hypertrophic scar is characterized by the overgrowth of fibroblasts and often considered as a kind of benign skin tumor, thus chemotherapeutic drugs have been used to treat scars. In view of the similarity, this study aims to investigate whether drug resistance in cancer that contributes to the failure of chemotherapy also exists in hypertrophic scar, and what is the possible mechanism. Fibrobl...

Fibroblasts comprise the largest cell population in the myocardium. In heart disease, the number of fibroblasts is increased either by replication of the resident myocardial fibroblasts, migration and transformation of circulating bone marrow cells, or by transformation of endothelial/epithelial cells into fibroblasts and myofibroblasts. The primary function of fibroblasts is to produce structu...

Cellular senescence, a state of permanent cell cycle arrest, is one the hallmarks tissue aging and age-related disorders. Stromal cells like fibroblasts, present in connective tissues play pivotal role organ homeostasis aging. We previously showed that senescent fibroblasts profoundly accumulated skin during Under some transient conditions, can be successfully removed by innate immune system, s...

Background. One of the common complications Crohn’s disease is development fibrotic changes in wall large intestine, and, as a result, risk strictures. Morphometric study cellular composition intestine ­biopsy samples one extended links diagnostic criteria for inflammatory bowel diseases, which make it possible to predict disease. Changes number fibroblasts, components mesenchymal cells, can be...

Deep dermal wounds induce skin contraction as a result of the traction forcing exerted by (myo)fibroblasts on their immediate environment. These are cells that responsible for regeneration collagen is necessary integrity We consider several mathematical issues regarding models simulate forces (myo)fibroblasts. Since size (e.g. (myo)fibroblasts) much smaller than domain computation, one often co...

This project focuses on elucidating the pathogenic effects of iron overload due to erythrocyte extravasation in skin immune-tissue cell crosstalk leading lipodermatosclerosis and leg ulcer patients with chronic venous insufficiency. We generated a new mice model local iron-overload skin, via ID-injection iron-dextran (Fedx). Prussian blue staining proved that accumulates dermis dWAT these mice,...

Exosomes are small membrane vesicles secreted from a variety of cell types. Recent evidence indicates that human cells communicate with each other by exchanging exosomes. Cancer cells closely interact with neighboring stromal cells, and together they cooperatively promote disease via bidirectional communication. Here, we investigated whether exosomes can play roles in intercellular communicatio...