OBJECTIVE The objective of the study was to determine the feasibility of detecting fetal brain lactate, a marker of fetal metabolic acidemia, using a noninvasive technique, proton magnetic resonance spectroscopy ((1)H MRS), in intrauterine growth-restricted (IUGR) fetuses. STUDY DESIGN In vivo human fetal brain lactate detection was determined by (1)H MRS in 5 fetuses with IUGR. Oxygenation a...

We report on the detection of discordant inclusions in the brain of a 25-week female fetus with a very rare lysosomal storage disease, namely, Sly disease (mucopolysaccharidosis (MPS) type VII), presenting with nonimmune hydrops fetalis. Besides vacuolated neurons, we found abundant deposition of polyglucosan bodies (PGBs) in the developing brain of this fetus in whom MPS-VII was corroborated b...

Background Congenital heart disease (CHD) is associated with brain dysmaturation, increased risk of perioperative white matter (WM) injury and neurodevelopmental delay (1). Fetal Doppler studies have shown altered cerebrovascular flow dynamics in CHD, suggesting ‘brain-sparing physiology’. We sought to determine whether postnatal cerebral WM microstructural abnormality relates to abnormal fetal...

Auditory evoked responses between right- and left-hemispheric derivations were investigated in 53 recordings from fetuses in the third trimester using fetal magnetoencephalography (fMEG). The side-different latency development of the component P2pm suggests an earlier maturation of certain right than homologous left hemispheric brain areas during fetal brain development.

OBJECTIVE To study whether maternal cigarette smoking during pregnancy is associated with alterations in the growth of fetal lungs, kidneys, liver, brain, and placenta. DESIGN A case-control study, with operators performing the image analysis blinded. SETTING Study performed on a research-dedicated magnetic resonance imaging (MRI) scanner (1.5 T) with participants recruited from a large tea...

conclusions: normothermia and hemodynamic stability are the most important factors which help to reduce fetal loss during open heart surgery in pregnancy. the fetus has an auto-regulation which comes into play when the mother is experiencing shock. objectives: the aim of this study was to report our experience with urgent cardiopulmonary bypass carried out in early pregnancy and to analyze fact...

neospora caninum, an apicomplexan protozoan, is regarded as a major cause of abortion and stillbirth in cattle in countries world-wide. the ability to detection n.caninum in tissue samples can be a useful detection diagnostic tool for use in the study of the pathogenicity, immunoprophylaxis, and treatment of neospora infection. however, molecular biology is one of the most sensitive tools for d...

Suboptimal developmental environments program offspring to lifelong metabolic problems. The aim of this study was to determine the impact of protein restriction in pregnancy on maternal liver lipid metabolism at 19 days of gestation (dG) and its effect on fetal brain development. Control (C) and restricted (R) mothers were fed with isocaloric diets containing 20 and 10% of casein. At 19 dG, mat...

In fetuses with complex congenital heart disease (CHD), impaired brain growth and development starts in utero. A interplay between heart, brain, body placenta takes place the second third trimesters of pregnancy. Altered fetal cardiovascular hemodynamics due to differnt types CHD lead altered cerebral, placental perfusion, all factors contributing maturational delay development. Impaired cerebr...