نتایج جستجو برای: fatty acid elongase gene

تعداد نتایج: 1796572  

2011
Xiaozhong Zheng Douglas R. Tocher Cathryn A. Dickson Alan J. Teale

Fish are an important source of the n-3 highly unsaturated fatty acids (HUFA), 1 eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids that are crucial to the health of higher 2 vertebrates. The synthesis of HUFA involves enzyme-mediated desaturation, and a ∆5 fatty acyl 3 desaturase cDNA has been cloned from Atlantic salmon (Salmo salar) and functionally 4 characterized previously. Here we re...

Journal: :Biochimica et biophysica acta 1999
C Ghioni D R Tocher M V Bell J R Dick J R Sargent

The TF cell line, derived from a top predatory, carnivorous marine teleost, the turbot (Scophthalmus maximus), is known to have a limited conversion of C18 to C20 polyunsaturated fatty acids (PUFA). To illuminate the underlying processes, we studied the conversions of stearidonic acid, 18:4(n-3), and its elongation product, 20:4(n-3), in TF cells and also in a cell line, AS, derived from Atlant...

بابا احمدی رضایی, حسین, دوستی, محمود, منتخب یگانه, حسین,

Background: Several dietary factors are involved in cardiovascular coronary heart diseases, including trans fatty acids, which are generally formed during hydrogenation of vegetable oils, a process that causes conversion of liquid oils into semisolid fats. Nowadays, it is well-known that trans fatty acids form a major risk factor in the occurrence and progression of atherosclerosis. On the ot...

Journal: :Journal of lipid research 2014
Stephan Laggai Sonja M Kessler Stefan Boettcher Valérie Lebrun Katja Gemperlein Eva Lederer Isabelle A Leclercq Rolf Mueller Rolf W Hartmann Johannes Haybaeck Alexandra K Kiemer

Liver-specific overexpression of the insulin-like growth factor 2 (IGF2) mRNA binding protein p62/IGF2BP2-2 induces a fatty liver, which highly expresses IGF2 Because IGF2 expression is elevated in patients with steatohepatitis, the aim of our study was to elucidate the role and interconnection of p62 and IGF2 in lipid metabolism. Expression of p62 and IGF2 highly correlated in human liver dise...

Journal: :PLoS ONE 2007
Kumar S.D. Kothapalli Joshua C. Anthony Bruce S. Pan Andrea T. Hsieh Peter W. Nathanielsz J. Thomas Brenna

BACKGROUND Docosahexaenoic acid (DHA, 22:6n-3) and arachidonic acid (ARA, 20:4n-6) are the major long chain polyunsaturated fatty acids (LCPUFA) of the central nervous system (CNS). These nutrients are present in most infant formulas at modest levels, intended to support visual and neural development. There are no investigations in primates of the biological consequences of dietary DHA at level...

Journal: :The Journal of nutrition 2011
Sheila K Jacobi Xi Lin Benjamin A Corl Holly A Hess Robert J Harrell Jack Odle

Because dietary arachidonate (ARA) and its eicosanoid derivatives are major regulators of intestinal homeostasis and repair following injury, we evaluated the effects of dietary ARA on desaturation and elongation of (13)C-18:2(n-6) and mRNA abundance of Δ-6-desaturase (FADS2), elongase (ELOVL5), and Δ-5-desaturase (FADS1) in liver and intestine. Day-old pigs (n = 96) were fed milk-based formula...

Journal: :Proceedings. Biological sciences 2010
Jennifer M Urbanski Joshua B Benoit M Robert Michaud David L Denlinger Peter Armbruster

Photoperiodic diapause is a crucial adaptation to seasonal environmental variation in a wide range of arthropods, but relatively little is known regarding the molecular basis of this important trait. In temperate populations of the mosquito Aedes albopictus, exposure to short-day (SD) lengths causes the female to produce diapause eggs. Tropical populations do not undergo a photoperiodic diapaus...

Journal: :The Journal of biological chemistry 2006
Shilpi Paul Kenneth Gable Frédéric Beaudoin Edgar Cahoon Jan Jaworski Johnathan A Napier Teresa M Dunn

Several 3-keto-synthases have been studied, including the soluble fatty acid synthases, those involved in polyketide synthesis, and the FAE1-like 3-ketoacyl-CoA synthases. All of these condensing enzymes have a common ancestor and an enzymatic mechanism that involves a catalytic triad consisting of Cys, His, and His/Asn. In contrast to the FAE1-like family of enzymes that mediate plant microsom...

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