نتایج جستجو برای: estrogenicity
تعداد نتایج: 335 فیلتر نتایج به سال:
Polystyrene is frequently used in resins, and the styrene dimers and trimers eluted from polystyrene have been reported to have estrogenic activity (1). We have performed a number of in vitro and in vivo tests [i.e., estrogen receptor (ER) and androgen receptor binding assays, thyroid hormone receptor binding assays, human breast cancer cell line MCF-7 proliferation assays (E-SCREEN), uterotrop...
The wide chemical diversity of estrogenic compounds precludes an accurate prediction of estrogenic activity on the basis of chemical structure or radioimmunological assay and thus requires that the potency of these compounds is defined by bioassay. The mammary duct growth response in intact prepubertal and adult gonadectomized female and male mice of the C3H/Di strain was used to assess the est...
CONTEXT: Dental sealants and composite filling materials containing bisphenol A (BPA) derivatives are increasingly used in childhood dentistry. Evidence is accumulating that BPA and some BPA derivatives can pose health risks attributable to their endocrine-disrupting, estrogenic properties. OBJECTIVES: To systematically compile and critically evaluate the literature characterizing BPA content o...
Abstract Background Fresh water bodies represent less than 1% of overall amount on earth and ensuring their quality sustainability is pivotal. Although several campaigns have been performed to monitor the occurrence micropollutants by means chemical analysis, this might not cover whole set chemicals present in sample nor potential toxic effects mixtures natural anthropogenic chemicals. In sense...
Severe developmental and reproductive disorders in wild animals have been linked to high exposure to persistent environmental chemicals with hormonal activity. These adverse effects of environmental estrogens have raised considerable concern and have received increasing attention. Although numerous chemicals with the capacity to interfere with the estrogen receptor (ER) have been identified, in...
The aim of this study was to compare results obtained by eight different short-term assays of estrogenlike actions of chemicals conducted in 10 different laboratories in five countries. Twenty chemicals were selected to represent direct-acting estrogens, compounds with estrogenic metabolites, estrogenic antagonists, and a known cytotoxic agent. Also included in the test panel were 17beta++-estr...
Plastic Products Leach Chemicals That Induce <i>In Vitro</i> Toxicity under Realistic Use Conditions
Plastic products contain complex mixtures of extractable chemicals that can be toxic. However, humans and wildlife will only exposed to plastic are released under realistic conditions. Thus, we investigated the toxicological chemical profiles leaching into water from 24 everyday covering eight polymer types. We performed migration experiments over 10 days at 40 °C analyzed migrates using four i...
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