Various methods have been used to obtain blood samples from unrestrained rhinoceros. Without extensive prior training, the results are generally poor due to pain avoidance reactions. However a new dermal anesthesia technique previously used in humans, an eutectic mixture of lidocaine and prilocaine, made it possible to obtain blood samples from the ear veins of one male and two female white rhi...

Recently, it has been demonstrated that particulate substances penetrate preferentially into the hair follicles and that the penetration depth depends on the particle size. In the present study, the influence of the vehicle of the particulate substances on the penetration depth was investigated. Four different formulations (ethanolic suspension, aqueous suspension, ethanolic gel and aqueous gel...

Atopic dermatitis (AD) is a chronic, relapsing, inflammatory skin disease characterized by pruritus and eczematous lesions. It has been described that the repeated topical application of hapten oxazolone to ears sensitized mice cause lesions mimic some features AD. However, in most published reports number challenges significantly high (6 12), which translates into long duration assay causing s...

A 27-year-old woman was admitted for intractable right-sided neck, ear, and jaw pain with gradual development of tinnitus and hearing loss. A cerebral MRI showed meningo-dural enhancement, and additional diagnostic workup revealed a right pulmonary infiltrate and positive PR-3 ANCA. Biopsies from nasal mucosa and lung showed chronic inflammation with granuloma formation. Based on these findings...

osteoma is a benign, slow-growing osteogenic tumor that sometimes arises from the craniomaxillofacial region, such as the sinus, temporal or jaw bones. osteoma consists of compact or cancellous bone that may be peripheral, central or extraskeletal type. peripheral osteoma arises from the periosteum and is commonly a unilateral, pedunculated mushroom-like mass. peripheral osteoma of the mandible...

Although Notch1 and Notch2 are closely related paralogs and function through the same canonical signaling pathway, they contribute to different outcomes in some cell and disease contexts. To understand the basis for these differences, we examined in detail mice in which the Notch intracellular domains (N1ICD and N2ICD) were swapped. Our data indicate that strength (defined here as the ultimate ...

Although Notch1 and Notch2 are closely related paralogs and function through the same canonical signaling pathway, they contribute to different outcomes in some cell and disease contexts. To understand the basis for these differences, we examined in detail mice in which the Notch intracellular domains (N1ICD and N2ICD) were swapped. Our data indicate that strength (defined here as the ultimate ...

it is vital in every language classroom that the best pos- sible materials be chosen as they are considered to play the next most important role in learning a foreign language after the teacher. all teachers are responsible to evaluate what they intend to take to the language classroom. these days, language teachers have the preference to equip their classes with technology as a supplement to b...

Mutations in Norrin, the ligand of a receptor complex consisting of FZD4, LRP5 and TSPAN12, cause severe developmental blood vessel defects in the retina and progressive loss of the vascular system in the inner ear, which lead to congenital blindness and progressive hearing loss, respectively. We now examined molecular pathways involved in developmental retinal angiogenesis in a mouse model for...

The Delta/Notch‑like epidermal growth factor‑related receptor (DNER) serves an important role in the developing central nervous system. However, the actions of DNER in the development of the spiral ganglion in the inner ear have yet to be elucidated. Wild‑type C57BL/6 mice were housed and time‑mated for use in the present study. Primary neuronal cultures were prepared using spiral ganglion prog...