Cartilage lesions change the microenvironment of cells and may accelerate cartilage degradation through catabolic responses in chondrocytes. In this study, we investigated the effects of structural integrity of extracellular matrix (ECM) on chondrocytes by comparing the mechanics of cells surrounded by an intact ECM with cells close to a cartilage lesion using experimental and numerical methods...

A country's economic development is significantly influenced by growth. nation can use growth indicators to inform its policy decisions and help it achieve objectives. This study aims examine the effect of inflation, exports imports, on Indonesia's between 1990 2020. There are a number issues in this study, error correction model, or ECM, model used data determine how resolve these (Error Corre...

Productive cell migration requires the spatiotemporal coordination of cell adhesion, membrane protrusion, and actomyosin-mediated contraction. Integrins, engaged by the extracellular matrix (ECM), nucleate the formation of adhesive contacts at the cell's leading edge(s), and maturation of nascent adhesions to form stable focal adhesions constitutes a functional switch between protrusive and con...

Integrins have emerged as key sensory molecules that translate chemical and physical cues from the extracellular matrix (ECM) into biochemical signals that regulate cell behavior. Integrins function by clustering into adhesion plaques, but the molecular mechanisms that drive integrin clustering in response to interaction with the ECM remain unclear. To explore how deformations in the cell-ECM i...

Reversible changes in lung microstructure accompany lung inflammation, although alterations in tissue micromechanics and their impact on inflammation remain unknown. This study investigated changes in extracellular matrix (ECM) remodeling and tissue stiffness in a model of LPS-induced inflammation and examined the role of lipoxin analog 15-epi-lipoxin A4 (eLXA4) in the reduction of stiffness-de...

Plasmodium falciparum malaria is responsible for nearly one million annual deaths worldwide. Because of the difficulty in monitoring the pathogenesis of cerebral malaria in humans, we conducted a study in various mouse models to better understand disease progression in experimental cerebral malaria (ECM). We compared the effect on the integrity of the blood brain barrier (BBB) and the histopath...

We present JKL-ECM, an implementation of the elliptic curve method of integer factorization which uses certain twisted Hessian curves in a family studied by Jeon, Kim and Lee. This implementation takes advantage of torsion subgroup injection for families of elliptic curves over a quartic number field, in addition to the ‘small parameter’ speedup. We produced thousands of curves with torsion Z/6...

In multicellular organisms, proteins of the extracellular matrix (ECM) play structural and functional roles in essentially all organs, so understanding ECM protein organization in health and disease remains an important goal. Here, we used sub-diffraction resolution stochastic optical reconstruction microscopy (STORM) to resolve the in situ molecular organization of proteins within the kidney g...