A total of 291 unvaccinated sheep from Brucella melitenesis-infected flocks were examined for delayed-type hypersensitivity (DTH) responses with Brucellergene commercial allergen and with cold saline extract and cytosol from rough B. melitensis 115, and their sera were tested in the rose bengal test (RBT), complement fixation test (CFT), and enzyme-linked immunosorbent assay (ELISA) with lipopo...

INTRODUCTION Among HIV-1-infected patients, CD4+ T cell counts are well-established markers of cell-mediated immunity. Delayed-type hypersensitivity (DTH) skin tests can be used to evaluate in vivo cell-mediated immunity to common antigens. METHODS DTH responses to tuberculin purified protein derivative (PPD), sporotrichin, trichophytin, candidin and streptokinase/streptodornase antigens were...

The influence of neonatal handling on behavior and immune function was assessed in Orange-winged Amazon parrots (Amazona amazonica). Chicks (n=11) were gently handled daily from 25 days of age until 38 days post-fledging, while control chicks (n=9) were not handled. At 10 days post-fledging ( approximately 66 days of age), chicks were given tests to evaluate tameness (e.g., willingness to perch...

mune response. It has been demonstrated to correlate with stage of disease (1, 6, 16, 31) and prognosis (2, 3, 14, 20) in many types of cancer. By various mechanisms, including surgery (17, 18), radiotherapy (8, 23), chemotherapy (23), and immunotherapy (11, 15, 32, 33), the human immune response can be altered.These changes can be docu mented with DTH skin tests, and thus this test of immuno l...

The results of this study show that during growth of the immunogenic Meth A fibrosarcoma, two different types of suppressor T lymphocytes are generated in sequence. One type is generated during early tumor growth, reaches peak number around day 6, and is progressively lost thereafter. It is defined by its ability, upon passive transfer, to suppress the expression of a DTH reaction to tumor anti...

Infection with Trypanosoma cruzi, the agent of Chagas' disease, may induce antibodies and T cells reactive with self antigens (autoimmunity). Because autoimmunity is generally thought to develop during the chronic phase of infection, one hypothesis is that autoimmunity develops only after long-term, low-level stimulation of self-reactive cells. However, preliminary reports suggest that autoimmu...

There is considerable evidence in animal tumor systems that antitumor immunity is modulated by suppressor T-lymphocytes, and that the cytotoxic drug cyclophosphamide (CY) can abrogate that suppression. We measured the acquisition of delayed-type hypersensitivity (DTH) to autologous melanoma cells in 19 patients with metastatic malignant melanoma. The patients were treated with an autologous mel...

face injury. Considering the onset of corneal infiltration, the cause of corneal infiltrate in this case appears to be delayed type hypersensitivity (DTH) reaction. DTH reaction takes 2 to 3 days to develop, and foreign materials act as haptens that conjugate with proteins, the complex of which combines with T lymphocytes, leading to an inflammatory response [1,2]. A previous study showed that ...