The drug fenofibrate has received major attention as a novel medical treatment for diabetic retinopathy (DR) and other diabetes-induced microvascular complications. This interest stems from two recent large, well-designed clinical trials that demonstrated large reductions in the progression of DR and the need for laser intervention, in addition to a reduction in renal and neurological outcomes,...

BACKGROUND Dietary restriction (DR) has been shown to prolong longevity across diverse taxa, yet the mechanistic relationship between DR and longevity remains unclear. MicroRNAs (miRNAs) control aging-related functions such as metabolism and lifespan through regulation of genes in insulin signaling, mitochondrial respiration, and protein homeostasis. RESULTS We have conducted a network analys...

PURPOSE To investigate the modulatory effect of rat bone marrow mesenchymal stem cells (MSC) on human corneal epithelial cells (HCE-T) stimulated with pro-inflammatory cytokines interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α) in an in vitro co-cultured model. METHODS HCE-T alone and co-cultured with MSC were stimulated with IFN-γ/TNF for 24 and 48 hours or left untreated. The...

The developmental process is a highly complicated process for building multicellular organisms. JMCB has published several research works in recent collections on this topic (Wu, 2013, 2014). In the present issue, five more articles report new biological factors and cell signaling pathways that are discovered controlling the developmental process. These findings might provide new insights into ...

Demand response (DR) has many beneficiaries in the electricity market. There are independent players who are interested in DR, which include: transmission system owners, distributors, retailers, and aggregators. In this paper DR is introduced as a tradable commodity that can be exchanged between DR buyers and sellers in a pool-based market which is called demand response exchange (DRX). DRX ope...

background over the past few decades diabetes has emerged as an important non-communicable disease in subsaharan africa (ssa). sight loss from diabetic retinopathy (dr) can be prevented with screening and early treatment. the objective of this paper is to outline the required actions and considerations in the planning and development of dr screening services.   methods a multiple-case study app...

*Corresponding author: Dr. Sudhakar Akulapalli, Assistant Professor/ Staff Scientist II, Creighton University School of Medicine and University of Nebraska Medical Center, Director & Coordinator: Cell Signaling and Tumor Angiogenesis Laboratory, Boys Town National Research Hospital, 555 N, 30th Street, Omaha NE 68131 USA, Tel: # (402) 4986681; Fax: (402) 498-6331; E-mail: [email protected]

Monomorphic MHC class II determinants are attractive targets for immunomodulation. HLA-DR ligation on antigen-presenting cells (APCs) can dramatically alter their function or induce cell death. In monocytes, HLA-DR triggering diminishes their capacity to stimulate T cell proliferation. To further investigate this monocyte-dependent T cell inhibition, we activated human T cells +/- HLA-DR trigge...