BACKGROUND In early-phase studies with targeted therapeutics and radiotherapy, it may be difficult to decide whether an adverse event should be considered a dose-limiting toxicity (DLT) of the investigational systemic agent, as acute normal tissue toxicity is frequently encountered with radiation alone. We have reanalyzed the toxicity data from a recently conducted phase 1 study on vorinostat, ...

a Department of physics, faculty of science, Takestan Branch, Islamic Azad University,Takestan, IRAN. b Engineering Department, Shahid Beheshti University, G.C., P.O. Box 1983963113, Tehran, IRAN. ________________________________________________________________________________________ Abstract: Absorption dose distribution of onion powder in electron irradiation system has been numerically inve...

The influence of electron beam lithography parameters (such as energy, resist thickness, the exposure dose) on sidewall shape (profile) was studied for PMMA (polymethyl-methacrylate) positive resist. profile tone investigated depending varying doses thicknesses 600 and 1300 nm, energy 30 keV. Simulation results based measurements along depth are presented discussed. obtained contribute to knowl...

PURPOSE Intensity modulated radiation therapy (IMRT) is a high precision therapy technique that can achieve a conformal dose distribution on a given target. However, organ motion induced by respiration can result in significant dosimetric error. Therefore, this study explores the dosimetric error that result from various patterns of respiration. MATERIALS AND METHODS Experiments were designed...

Purpose: Phase I clinical trials are generally conducted to identify themaximum tolerated dose (MTD) or the biologically active dose (BAD) using a traditional dose-escalation design. This designmaynot be applied to cancer vaccines, given their unique mechanism of action. The FDA recently published "Guidance for Industry: Clinical Considerations for Therapeutic Cancer Vaccines." However, many qu...

Monensin is a common feed additive used in various countries, where 1 of the associated benefits for use in beef cattle is improved efficiency of energy metabolism by the rumen bacteria, the animal, or both. Modeling fermentation-altering supplements is of interest, and thus, it is the purpose of this paper to quantify the change in VFA profile caused by monensin dose in high-grain-fed beef cat...

PURPOSE Rigosertib, a dual non-ATP inhibitor of polo-like kinase 1 (Plk1) and phosphoinositide 3-kinase pathways (PI3K), and gemcitabine have synergistic antitumor activity when combined in preclinical studies. This phase I study aimed to determine the recommended phase II dose (RPTD) of the combination of rigosertib and gemcitabine in patients with cancer. EXPERIMENTAL DESIGN Patients with s...

PURPOSE Carcinoma in situ represents high grade anaplasia of the bladder mucosa. Intravesical immunotherapy with bacillus Calmette-Guérin is the gold standard treatment for patients with carcinoma in situ. Patients with carcinoma in situ refractory to bacillus Calmette-Guérin are candidates for major surgery such as radical cystectomy. We identified the maximum tolerated dose and the recommende...

Introduction: Total skin electron irradiation technique is used in treatment of the mycosis fungoid. The implementation of this technique requires non-standard measurements and complex dosimetry methods. Operating procedures for total skin electron irradiation and its dosimetry vary in different radiation therapy centers in the world. In this article, validation of TSET techniq...