Methods We searched in Pubmed and Cochrane-central-registerfor-controlled-trials for all NI RCTs of direct thrombin inhibitors (DTI) and direct inhibitors of factor Xa (DXAI) for prophylaxis of VTE. All NI trials had enoxaparin as their active comparator. Using the draft FDA guidelines for NI trials, we determined an NI margin, referred to as the reference NI margin, based on all published plac...

The most common method for detection of drug resistant (DR) TB in resource-limited settings (RLSs) is indirect susceptibility testing on Lowenstein-Jensen medium (LJ) which is very time consuming with results available only after 2-3 months. Effective therapy of DR TB is therefore markedly delayed and patients can transmit resistant strains. Rapid and accurate tests suitable for RLSs in the dia...

The dried fruit of Terminalia chebula is widely used for its laxative properties. The objective of the present study was to examine the flowability and compressibility of Terminalia chebula fruit powder, subsequently developing its tablet formulations by utilizing wet granulation and direct compression technology. Initial studies on flowability and compressibility revealed that the fruit powder...

BACKGROUND/AIMS Molecular diagnostic methods have enabled the rapid diagnosis of drug-resistant mutations in hepatitis B virus (HBV) and have reduced both unnecessary therapeutic interventions and medical costs. In this study we evaluated the analytical and clinical performances of the HepB Typer-Entecavir kit (GeneMatrix, Korea) in detecting entecavir-resistance-associated mutations. METHODS...

Deaf and hard-of-hearing (DHH) children's ability to rapidly learn novel words through direct reference and through novel mapping (i.e., inferring that a novel word refers to a novel object) was examined. Ninety-eight DHH children, ranging from 27 to 82 months old, drawn from 12 schools in five states participated. In two tasks that differed in how reference was established, word-learning abili...

Abstract— Improving the transient performance of the MRAC has been a point of research for a long time. The main objective of the paper is to design an MRAC with improved transient and steady state performance. This paper proposes a Fuzzy modified MRAC (FMRAC) to control a coupled tank level process. The FMRAC uses a proportional control based Mamdani-type Fuzzy inference system (MFIS) to impro...

background: mental disorders may lead to several complications in adolescents’ people whose compensation is very difficult and sometime impossible. they are prone to emotional problems. therefore, knowing prevalence of diseases and valid statistical technique is necessary to plan for prevention and control of diseases. methods: in this cross-sectional study; direct, synthetic, and post-stratifi...

Naturalists who conceive of knowledge as a natural kind are led to treat ‘knowledge’ as a natural kind term. ‘Knowledge,’ then, must behave semantically in the ways that seem to support a direct reference theory for other natural kind terms. A direct reference theory for ‘knowledge,’ however, appears to leave open too many possibilities about the identity of knowledge. Intuitively, states of be...

A study is described on the standardization of the determination of neonatal total bilirubin. A wide variation in results was shown in surveys held in The Netherlands and Germany and the reasons for this variation were sought. The suitability of commercial bilirubin standards and direct reading instruments, widely used in the neonatal field, was tested by comparing all measurements with those o...

The word 'holography' means a drawing that contains all of the information for light-both amplitude and wavefront. However, because of the insufficient bandwidth of current electronics, the direct measurement of the wavefront of light has not yet been achieved. Though reference-field-assisted interferometric methods have been utilized in numerous applications, introducing a reference field rais...