Diabetes is justly recognized as an emerging global epidemic, representing one of the leading causes of morbidity and mortality worldwide. Hyperglycemia, the common characteristic of both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM), has the potential to cause serious complications due to its insidious and chronic nature. The present special issue has been designed to pub...

In diabetes mellitus, thickening of basement membrane in capillaries and small vessels is a well-known finding and important in the progression of diabetic microangiopathy. We evaluated whether the plasma levels of type IV collagen and fibronectin, which are important factors of basement membrane, are related with the presence of diabetic microangiopathy. Plasma type IV collagen and fibronectin...

OBJECTIVE To investigate the relationships of serum adipocyte fatty acid-binding protein (A-FABP) and epidermal fatty acid-binding protein (E-FABP) with renal dysfunction and macrovascular complications in type 2 diabetic patients. RESEARCH DESIGN AND METHODS The associations of serum A-FABP and E-FABP with markers of renal function, nephropathy staging, and macrovascular complications were e...

Observational and clinical trial data show a clear relationship between the degree of hyperglycemia and the risk to develop diabetic retinopathy, diabetic nephropathy and diabetic neuropathy. Intervention trials comparing two different levels of glycemic control demonstrate that for every 1% reduction in HbA 1c , there is approximately a 25-30% reduction in these complications of diabetes. Furt...

Oxidative stress has been paid increasing attention to as an important causative factor for diabetic vascular complications. Among possible various sources, accumulating evidence has indicated that NAD(P)H oxidase may be the most important source for reactive oxygen species production in diabetic vascular tissues. The mechanisms underlying activation and up-regulation of NAD(P)H oxidase has bee...

OBJECTIVE To determine the prevalence of chronic complications and associated factors in type 2 diabetes in 500 diabetic patients, age > or = 25 years, attending the clinic of Diabetic Association of Pakistan (DAP), Karachi. METHODS Every 5th registered diabetic patient > or = 25 years age, was examined for the presence/absence of micro and macro vascular complications and associated factors....

background: in addition to macrovascular and along with other microvascular complications, diabetic patients suffer from some common musculoskeletal complications. the aim of this study was to assess the prevalence of five musculoskeletal disorders of upper extremity including shoulder capsulitis (sc), limited joint mobility (ljm), dupuytren’s contracture (dc), carpal tunnel syndrome (cts), and...

Corresponding author: Min Young Chung Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, 8 Hak-dong, Dong-gu, Gwangju 501-757, Korea E-mail: [email protected] We appreciate the interest and comments on our study, “Association between diabetic polyneuropathy and cardiovascular complications in type 2 diabetic patients,” whic...

BACKGROUND The epidemiology of diabetes and Ramadan fasting was reported from many Muslim countries, but not from Libya. METHODOLOGY We interviewed 493 consecutive diabetic patients at Benghazi Diabetes and Endocrine Center for the potential complications of fasting during Ramadan. RESULTS We found 70% of diabetic patients completed the 30 days of Ramadan fasting. Hypo- and hyperglycemia wa...

Gangrene, infections like abscesses and ulcers are some of the common diabetic foot complications. Of all these, diabetic foot ulcers pose a major public health problem. Around 80% of all the lower limb amputations are preceded by a foot ulcer. There are various classifications for diabetic foot ulcers out of which the two commonly used classifications are Wagner’s ulcer classification and the ...