DACS (Database of available chemical compounds) was developed to design a HTS collection or focused libraries for the FMP Screening Unit. But the dramatically increase of unique compounds of one order of magnitude from less than 10 to around 30 to 40 million compounds currently and approximately hundred million compounds in the next years requires a reorganization and redevelopment of the stora...

The utilization of microfluidic "lab-on-a-chip" devices in fundamental medical research, drug discovery and clinical diagnostics has rapidly increased in the past decade. Lab-on-a-chip devices process small volumes of analytes and reagents through on-chip microfluidic signal processing circuits. This paper discusses the implementation of a basic microfluidic circuit block, the concentration dig...

Almost all early-type stars show Discrete Absorption Components (DACs) in their ultraviolet spectral lines. These can be attributed to Co-rotating Interaction Regions (CIRs): large-scale spiral-shaped structures that sweep through the stellar wind. We used the Zeus hydrodynamical code to model the CIRs. In the model, the CIRs are caused by " spots " on the stellar surface. Through the radiative...

A future maskiess lithography system that replaces traditional masks with an array of electro-mechanical mirrors relies on a very high rate data interface to achieve the wafer throughputs comparable to today's optical lithography systems. In order to write one layer per minute in 45nm technology node, a throughput of l2Tb/s using 5-bit grayscale data is needed. With EUV light source flash rates...

Current implementations of UNIX offer security features in the form of discretionary access controls (DACs). DACs are implemented with file access permissions and access control lists (ACLs). Unfortunately, neither of these facilities provide for access control to active processes. In order to provide many users access to a process (and its associated data) the current practice at our site is t...

Borderline personality disorder (BPD) is characterized by affective instability, unstable relationships, and identity disturbance. We measured salivary alpha-amylase (sAA) and salivary cortisol levels in all participants during exposure to the Trier Social Stress Test (TSST) and an electric stimulation stress. Seventy-two BPD patients were compared with 377 age- and gender- matched controls. Th...

Dialysis vascular access planning, creation, and management is of critical importance to the dialysis patient population. It requires a multidisciplinary approach involving patients and their families, dialysis facility staff, the nephrologist, the surgeon, and the interventionalist. With the emergence of interventional nephrology as a subspecialty of nephrology, the nephrologist is increasingl...

The long links that interconnect networking and computing systems and boards need high throughput to avoid expensive, massively parallel connections. However, long wires suffer signal losses that increase with frequency. Digital communication techniques can compensate for these losses, but require Analog-to-Digital and Digital-to-Analog converters (ADCs and DACs). To understand the application ...