نتایج جستجو برای: cyp2d6

تعداد نتایج: 2395  

Journal: :Pharmacological reports : PR 2012
Małgorzata Barańska Bożena Dziankowska-Bartkowiak Elżbieta Waszczykowska Mariola Rychlik-Sych Jadwiga Skrętkowicz

BACKGROUND Systemic sclerosis (SSc) belongs to the group of systemic diseases of the connective tissue, which are characterized by a chronic autoimmune inflammatory process. The studies on etiopathogenesis of autoimmune diseases focus on the impact the genetically conditioned impairment of xenobiotic metabolism may exert. The genetically polymorphic CYP2D6 is one of the most important phase I d...

2014
M A Province M P Goetz H Brauch D A Flockhart J M Hebert R Whaley V J Suman W Schroth S Winter H Zembutsu T Mushiroda W G Newman M-T M Lee C B Ambrosone M W Beckmann J-Y Choi A-S Dieudonné P A Fasching R Ferraldeschi L Gong E Haschke-Becher A Howell L B Jordan U Hamann K Kiyotani P Krippl D Lambrechts A Latif U Langsenlehner W Lorizio P Neven A T Nguyen B-W Park C A Purdie P Quinlan W Renner M Schmidt M Schwab J-G Shin J C Stingl P Wegman S Wingren A H B Wu E Ziv G Zirpoli A M Thompson V C Jordan Y Nakamura R B Altman M M Ames R M Weinshilboum M Eichelbaum J N Ingle T E Klein

The International Tamoxifen Pharmacogenomics Consortium was established to address the controversy regarding cytochrome P450 2D6 (CYP2D6) status and clinical outcomes in tamoxifen therapy. We performed a meta-analysis on data from 4,973 tamoxifen-treated patients (12 globally distributed sites). Using strict eligibility requirements (postmenopausal women with estrogen receptor-positive breast c...

Journal: :Journal of postgraduate medicine 2006
R Ismail

BACKGROUND Genotypes of the drug-metabolizing enzyme CYP2D6 influence plasma levels of 25% of commonly prescribed drugs. This is the first study in India to investigate the genotype-phenotype relationship of CYP2D6. AIM To study the influence of some CYP2D6 genotypes on the metabolism of its substrate dextromethorphan in healthy South Indian volunteers and to assess the contribution of the CY...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2006
John P Gibbs Ruth Hyland Kuresh Youdim

Minimizing interindividual variability in drug exposure is an important goal for drug discovery. The reliability of the selective CYP2D6 inhibitor quinidine was evaluated in a retrospective analysis using a standardized approach that avoids laboratory-to-laboratory variation. The goal was to evaluate the reliability of in vitro metabolism studies for predicting extensive metabolizer (EM)/poor m...

Journal: :Pharmacological reports : PR 2014
Anna Wojtczak Maciej Wojtczak Jadwiga Skrętkowicz

BACKGROUND Metoprolol is the one of the most commonly used β-blockers in the treatment of ischemic heart disease and it is extensively metabolized in the liver undergoing oxidation by CYP2D6 isoenzyme of cytochrome P450. Gene encoding the CYP2D6 enzyme is characterized by genetic polymorphism. The CYP2D6 oxidation polymorphism has a major impact on the effectiveness and safety of the treatment....

Journal: :Journal of clinical psychopharmacology 2009
Rhee-Hun Kang Sun-Min Jung Kyoung-Ah Kim Duk-Ki Lee Hyun-Kee Cho Bong-Joo Jung Young-Ku Kim Seung-Hyun Kim Changsu Han Min-Soo Lee Ji-Young Park

This study was conducted to evaluate the effects of the CYP2D6 and CYP3A5 genotypes on the steady-state plasma levels of risperidone (RIS), 9-hydroxyrisperidone (9-OH-RIS), and the active moiety (RIS plus 9-OH-RIS) in Korean schizophrenic patients. Sixty-four Korean schizophrenic patients were enrolled. CYP2D6 and CYP3A5 genotypes were determined, and the plasma levels of RIS and 9-OH-RIS were ...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2003
Amit S Kalgutkar Sue Zhou Odette A Fahmi Timothy J Taylor

The relationship between lipophilicity and CYP2D6 affinity of cyclic tertiary (N-alkyl-4-phenyl-1,2,3,6-tetrahydropyridines) and quaternary (N-alkyl-4-phenylpyridinium) amines was examined. The 1,2,3,6-tetrahydropyridine scaffold was chosen due to its common occurrence in the structures of CYP2D6 ligands such as the Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and...

2013
Mariola Rychlik-Sych Małgorzata Baranska Elzbieta Waszczykowska Jolanta Dorota Torzecka Agnieszka Zebrowska Jadwiga Skretkowicz

INTRODUCTION Bullous skin diseases, which include, among others pemphigoid, pemphigus, and dermatitis herpetiformis are classified as severe autoimmune dermatoses. It has been shown that a pattern of xenobiotic metabolism may play a role in the pathogenesis of autoimmune diseases. AIM To estimate whether the CYP2D6 genotype may be considered a predisposing factor in autoimmune bullous disease...

Journal: :Journal of the National Cancer Institute 2012
Meredith M Regan Brian Leyland-Jones Mark Bouzyk Olivia Pagani Weining Tang Roswitha Kammler Patrizia Dell'orto Maria Olivia Biasi Beat Thürlimann Maria B Lyng Henrik J Ditzel Patrick Neven Marc Debled Rudolf Maibach Karen N Price Richard D Gelber Alan S Coates Aron Goldhirsch James M Rae Giuseppe Viale

BACKGROUND Adjuvant tamoxifen therapy is effective for postmenopausal women with endocrine-responsive breast cancer. Cytochrome P450 2D6 (CYP2D6) enzyme metabolizes tamoxifen to clinically active metabolites, and CYP2D6 polymorphisms may adversely affect tamoxifen efficacy. In this study, we investigated the clinical relevance of CYP2D6 polymorphisms. METHODS We obtained tumor tissues and iso...

Studies on associations of various polymorphisms in xenobiotic metabolizing genes with different cancers including acute lymphoblastic leukaemia (ALL) are mixed and inconclusive. The current study analyzed the relationship between polymorphisms of phase I xenobiotic metabolizing enzymes, cytochromes P450 1A1 (CYP1A1) and CYP2D6 and childhood ALL in Kashmir, India. We recruited 200 confirmed ALL...

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