Hypolipidemic therapy is one of the essential components for management patients with cardiovascular diseases (CVD). In this regard, main task modern research to find new targets creating additional effective groups hypolipidemic medications. Canadian and French led by N. Seidah M. Abifadel discovered a enzyme — proprotein convertase subtilisin-kexin type 9 (PCSK9) in 2003. It turned out play a...

A hallmark of atherosclerotic cardiovascular disease (CVD) is the accumulation of cholesterol in arterial macrophages. Factors that modulate circulating and tissue cholesterol levels have major impacts on initiation, progression, and regression of CVD. Four members of the ATP-binding cassette (ABC) transporter family play important roles in this modulation. ABCA1 and ABCG1 export excess cellula...

The relationship between obesity, diabetes, hyperlipidemia, hypertension, kidney disease and cardiovascular disease (CVD) is established when looked at from a clinical, epidemiological or pathophysiological perspective. Yet, when viewed from a genetic perspective, there is comparatively little data synthesis that these conditions have an underlying relationship. We sought to investigate the ove...

Research has been conducted to develop a new means of producing large grained polycrystlline thin films for photovoltaic applications. The process is one of growth of controlled crystalline nuclei in an a-Si film. For this process to be practicle, we must develop a-Si films with crystallization behavior such that the rate of spontaneous crystallization (nucleation rate) is essentially zero at t...

The stretchability of CVD graphene with a large area is much lower than that of mechanically exfoliated pristine graphene owing to the intrinsic and extrinsic defects induced during its synthesis, etch-out of the catalytic metal, and the transfer processes. This low stretchability is the main obstacle for commercial application of CVD graphene in the field of flexible and stretchable electronic...

OBJECTIVE Psychosocial adversity is a risk factor for cardiovascular disease (CVD) in adults. The authors assessed associations of reactive hyperaemia peripheral arterial tonometry (RH-PAT), a measure of endothelial function predictive of CVD, with self-assessed psychological health among school children. METHODS A total of 248 healthy school children (mean (SD) age 14.0 (1.0); 136 girls and ...

Oxidative stress (OS) and inflammatory processes initiate the first stage of cardiovascular disease (CVD). Flavonoid consumption has been related to significantly improved flow-mediated dilation and blood pressure. Antioxidant and anti-inflammatory mechanisms are thought to be involved. The effect of flavonoids on markers of oxidative stress and inflammation, in at risk individuals is yet to be...

We use Y-stabilized ZrO2 (YSZ) as a promising single-crystal wafer material for the epitaxial growth of transition metal dichalcogenides applicable both physical (PVD) and chemical vapor deposition (CVD) processes. MoS2 layers grown on YSZ (111) exhibit 6-fold symmetry in-plane relationship with (1010) || (211) YSZ. The PVD sub-monolayer thin films show nucleation islands lateral size up to 100...

DESPITE WIDESPREAD PUBLIC BELIEF THAT PSYCHOlogical stress leads to disease, the biomedical community remains skeptical of this conclusion. In this Commentary, we discuss the plausibility of the belief that stress contributes to a variety of disease processes and summarize the role of stress in 4 major diseases: clinical depression, cardiovascular disease (CVD), human immunodeficiency virus (HI...

We have studied the nucleation and growth processes in a chemical vapor deposition (CVD) diamond film using a tomographic electron backscattering diffraction method (3D EBSD). The approach is based on the combination of a focused ion beam (FIB) unit for serial sectioning in conjunction with high-resolution EBSD. Individual diamond grains were investigated in 3-dimensions particularly with regar...