Abstract The acute respiratory distress syndrome (ARDS) is a major cause of failure with limited therapeutic options. Unresolving inflammation in the lungs and alveolar-capillary barrier dysfunction are main features ARDS. sharp increase incidence ARDS during COVID19 emphasized need for better understanding immunological events that inform novel therapeutics. Here, we used model self-limited ac...

Estrogen and progesterone induce production of macrophage colony-stimulating factor (CSF-1) by uterine epithelial cells, and CSF-1 is produced in the uterus during pregnancy in mice. CSF-1 is a lineage-specific stimulator of macrophage proliferation, chemotaxis, and function. High concentrations of macrophages accumulate in the uterus during pregnancy. Experiments were conducted to determine wh...