KID syndrome is a congenital ectodermal dysplasia characterized by the association of keratitis, hyperkeratotic skin lesions and neurosensorial hearing loss. Ocular involvement occurs in 95% of patients. Although KID syndrome cutaneous manifestations have been studied in-depth, the treatment and prognosis of ophthalmic impairment have not been described in detail. At present, the treatment of t...

Proper wound healing is vital for maintenance of corneal integrity and transparency. Corneal epithelial damage is one of the most frequently observed ocular disorders. Because clinical options are limited, further novel treatments are needed to improve clinical outcomes for this type of disease. In the present study, it was found that placental extract-derived dipeptide (JBP485) significantly i...

Chemical burns are a major cause of corneal injury. Oxidative stress, inflammatory responses and neovascularization after the chemical burn aggravate corneal damage, and lead to loss of vision. Although NADPH oxidases (Noxs) play a crucial role in the production of reactive oxygen species (ROS), the role of Noxs in chemical burn-induced corneal injury remains to be elucidated. In the present st...

PURPOSE To evaluate and compare the proinflammatory and apoptotic effects of lipopolysaccharide (LPS) in three rabbit corneal injury models using a new in vivo confocal microscope (IVCM) and immunohistological techniques. METHODS Adult male New Zealand albino rabbits were used in this study. Three corneal models were tested: corneal incision, corneal epithelium scraping, and corneal suture. T...

Laser Doppler holography (LDH) is a full-field blood flow imaging technique able to reveal human retinal and choroidal with high temporal resolution. We here report on using LDH in the anterior segment of eye without making changes instrument. Blood bulbar conjunctiva episclera as well corneal neovascularization can be effectively imaged. additionally demonstrate simultaneous holographic poster...

PURPOSE Corneal neovascularization remains an unsolved therapeutic problem. Platelet-derived growth factor (PDGF) is directly linked to vessel formation and stabilization. This study was undertaken to elucidate the mechanisms by which PDGF exerts its effects on corneal angiogenesis. METHODS Corneal neovascularization was induced in C57 mice by removal of the limbal epithelium. When mature ves...

We used computerized image analysis to evaluate quantitatively the ability of topically applied corticosteroids (dexamethasone sodium phosphate, prednisolone acetate), cyclooxygenase inhibitors (flurbiprofen, indomethacin, ketorolac), lipoxygenase inhibitors (REV 5901, esculetin, quercetin), and dual cyclooxygenase/lipoxygenase inhibitors (BW 755C, BW A540C) to reduce corneal neovascularization...

Objective: The objective of this selective EBM review is to determine whether or not Bevacizumab is an effective treatment in inhibiting the growth of recurrent pterygium. Study Design: Review of three published, English language randomized controlled trials published in 2010, 2012, and 2013. Data sources: Three randomized controlled trials measuring the efficacy of Bevacizumab to inhibit the g...

BACKGROUND Keratitis caused by herpes simplex virus (HSV) can have detrimental effects on the cornea leading to loss of vision. Modern therapies can contribute to the prevention of anatomical and functional damage. CASE REPORT An 80-year-old male with complicated HSV-1 keratitis of the left eye (confirmed diagnosis after microbiological investigation) presented three months after antiviral trea...

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