Isolated Phaseolus mitochondria will swell spontaneously in buffered KCl and contract with an oxidizable substrate or ATP + Mg(2+). The conditions under which the mitochondria are swollen affect subsequent contraction, substrate oxidation and ion accumulation, but not their oxidative phosphorylation ability. Bovine serum albumin reduces the rate of swelling and promotes substrate oxidation, con...

Flower of Rosa damascena Mill is widely used in Iran for gastrointestinal (GI) disorders. However, its pharmacological action on ileum contraction has not been studied. In this research we have investigated ileum motility effect of essential oil of flower petals of R. damascena growing in Kashan, Iran, and two of its constituents. The essential oils obtained by hydrodistillation were investigat...

Na+-K+-ATPase plays a major role in regulating membrane potential and vascular tone. We analyzed the modulation by norepinephrine (NE), endothelin-1 (ET-1), and phorbol 12-myristate 13-acetate (PMA) of Na+-K+-ATPase-induced cytoplasmic free Ca2+concentration ([Ca2+]i) reduction and relaxation in isolated endothelium-denuded piglet mesenteric arteries. KCl (0.2-8.8 mM)-induced [Ca2+]ireduction a...

Cajaninstilbene acid (CSA) is a major active component present in the leaves of Cajanus cajan (L.) Millsp. The present study explores the underlying cellular mechanisms for CSA-induced relaxation in rat renal arteries. Vascular reactivity was examined in arterial rings that were suspended in a Multi Myograph System and the expression of signaling proteins was assessed by Western blotting method...

Objective: In experimental models, animals with induced colitis have increased urinary frequency and abnormalities in bladder contraction to cholinergic and electric field stimulation (EFS). Nuclear factor kappa B (NFκB) is a major mediator of the inflammatory response in inflammatory bowel disease and syndrome. The aim of the present study was to determine the effect of increased NFκB signalli...

Objective: The goal of this study was to examine the effect in vivo melatonin (MEL) administration on isolated thoracic aorta rats with thyroxine treatment and its duty aortic response contractile agents, such as potassium chloride (KCl) phenylephrine (PE). In addition, immunohistological alterations were also examined.
 Methods: Experimental groups follows: control group (n= 5), 6), + 6)....

We studied the involvement of different types of Ca channels, cyclic nucleotides and different kinases in the regulation of human umbilical artery (HUA) contractility. The elucidation of the precise mechanisms regulating the contractility of this artery could be very important to reveal potential therapeutic targets to treat HUA disorders such as preeclampsia. The relevancy of different types o...

background: the petal’s hydro‑alcoholic extract of rosa damascena mill. on ileum contractions of wistar rats and its possible mechanism were investigated. methods: forty‑eight male wistar rats were divided into six groups. ileum was placed adjacent to propranolol (1 μm), naloxone (1 μm) and l‑name (100 μm) and also under the influence of different doses (2-8 mm) of calcium chloride. results: cu...