During the last few years concanavalin A has become the most widely known and intensively investigated phytohemagglutinin. Much of this interest stems from the discovery that this lectin possesses several remarkable biological properties. In addition to its role as a hemagglutinin,' a structural probe,' and a mitogen,"-" concanavalin A has been shown to restore normal growth patterns to transfo...

Friend erythroleukaemic cells can be induced to mature along the erythroid differentiation pathway when an inducing agent such as dimethyl sulphoxide is included in the medium. In the absence of the inducing agent, the 707B line of Friend erythroleukaemic cells is highly agglutinable by the lectins concanavalin A or wheat germ agglutinin. However, 48 h after the induction of differentiation, th...

It has been previously observed that rabbit erythrocyte cell surface galactosyltransferase appears to play a role in concanavalin A agglutination of these erythrocytes (Podolsky et al., 1974). Further, a correlation between the occurrence or level of cell surface galactosyltransferase and concanavalin A agglutinability of other cell types has also been observed. The mechanism by which rabbit er...