Early in cold acclimation (1-7 days), heat is produced by shivering, while late in cold acclimation (12-45 days), skeletal muscle contributes to thermogenesis by tissue metabolism other than contractions. Given that both thermogenic phases augment skeletal muscle aerobic power and reactive species production, we aimed in this study to examine possible changes in skeletal muscle antioxidative de...

The aim of the present study was to assess our hypothesis that the renin-angiotensin system (RAS) is responsible for cold-induced hypertension and cardiac hypertrophy. Two groups of wild-type (WT) mice and 2 groups of angiotensinogen gene knockout (Agt-KO) mice (6 per group) were used. After blood pressures (BP) of the four groups were measured 3 times at room temperature (25 degrees C), 1 WT a...

Thermal conditions in the bathroom and physiological responses were examined during winter and summer. The subjects were 22 male and 20 female elderly people, between 65 and 88 years old living in 25 houses in Gunma Prefecture, Japan. Heart rate, blood pressure, skin temperature and thermal sensation were measured during bathing. Changes in thermal sensation due to bathing were assessed in the ...

The objective was to determine whether the mineralocorticoid receptor (MR) plays a role in the initiation and development of cold-induced hypertension (CIH) by testing the hypothesis that the RNA interference (RNAi) inhibition of the MR attenuates CIH. The recombinant adeno-associated virus (AAV) carrying a short-hairpin small-interference RNA for MR (MRshRNA) or a scrambled sequence (Controlsh...

BACKGROUND Pain upon the injection of propofol is a common adverse effect. This study was conducted to evaluate the analgesic effect of remifentanil and cold propofol during propofol injection for the induction of anesthesia and to determine if a combination of cold propofol and remifentanil produced additional analgesic efficacy. METHODS A total of 160 patients aged 20-65 years old were rand...

Plasma is an ionized gas that is typically generated in high-temperature laboratory conditions. Recent progress in atmospheric plasmas led to the creation of cold plasmas with ion temperature close to room temperature. We have demonstrated the efficacy of cold plasma in a pre-clinical model of various cancer types (long, bladder, and skin). Both in-vitro and in-vivo studies revealed that cold p...

This study was designed to compare the activities of sarcoplasmic (SR) Ca2+-ATPase and Ca2+ uptake in fish and mammalian hearts and to determine whether thermal acclimation has any effect on the function of the cardiac SR in fish. To this end, we measured thapsigargin-sensitive Ca2+-ATPase activity and thapsigargin-inhibitable Ca2+ uptake velocity in crude cardiac homogenates of newborn and adu...

The yields of crystalline trypsin prepared by the original method (1) are generally far below the values to be expected if all of the trypsinogen were changed into trypsin. The specific activity of the enzyme also tends to be low. This is due to a second reaction (2) which occurs simultaneously with the transformation of trypsinogen into t iypsin--part of the trypsinogen is transformed into an ...

For diagnosing the hand-arm vibration syndrome, peripheral circulation and sensory tests immersing one hand in cold water at 10 degrees C for 10 min have been performed widely in Japan. The authors investigated the effects of room temperature, seasonal condition and food intake on the test results, especially finger skin temperature. Six healthy males were examined repeatedly under six differen...