Several aromatic compounds have been found to inhibit the gelling of sickle cell hemoglobin. We have tried to correlate the antigelling activity of such compounds with the stereo-chemistry of their binding sites in the hemoglobin molecule. This approach led to the discovery that two known antilipoproteinemia drugs, clofibrate and gemfibrozil, have antigelling activity. X-ray analysis showed tha...

Activities of the tricarboxylic acid cycle enzymes were measured in subcellular fractions of liver from rats that had been fed clofibrate for 3 weeks. Large changes in these activities per gram tissue were found in the large particle fraction, which also showed an increase in total protein concentration of 76% under clofibrate treatment. The three regulatory enzymes of the cycle, namely citrate...

The title compound, C(6)H(7)N(3), has an ethyl-ene group connecting an imidazole ring and a -CN group. These groups are in a staggered conformation. The shortest inter-molecular contact is found between the imidazole N atom and a -CH(2)- group of a neighboring mol-ecule.

The pyran ring of the title compound, C(13)H(18)N(2)O(3), is almost planar (r.m.s. deviation = 0.059 Å). The crystal packing is stabilized by N-H⋯O and N-H⋯N hydrogen bonds.

In the title compound, C(18)H(21)N(5)O(4), the diazepine ring adopts a boat conformation with the triazolylmethyl-bearing C atom as the prow and the C atoms at the ring junction as the stern.

The title compound, [Au(C(6)H(12)NOS)(C(18)H(15)P)], features a linear S,P-donor set about the central Au atom with a deviation from linearity [S-Au-P = 176.66 (5)°] due to an intra-molecular Au⋯O contact [2.991 (5) Å]. Supra-molecular dimers are formed in the crystal structure mediated by C-H⋯N inter-actions.

which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Hyperbilirubinemia is a common problem in Iranian newborns and constitutes approximately one third of admissions to our neonatal ward. Phototherapy is the most widely used form of therapy for the treatment of neonatal hyperbilirubinemia (1). There are some pharmacological ...

In the title compound, C(19)H(17)NO(5), the dihedral angle between the phenyl groups is 79.55 (15)°. The terminal eth-oxy group is disordered over two orientations in a 0.873 (6):0.127 (6) ratio. In the crystal, mol-ecules are linked by N-H⋯O and C-H⋯O hydrogen bonds into [001] chains which incorporate R(1) (2)(6) loops. A very weak C-H⋯π contact also occurs.

The title compound, [Au(C(9)H(9)ClNOS)(C(18)H(33)P)], features a slightly distorted linear coordination geometry for the Au atom defined by a S,P-donor set [S-Au-P = 177.62 (5)°]. The distortion is ascribed to the close approach of the O atom, which forms an intra-molecular contact of 2.970 (5) Å. Disorder was found in the structure with two positions of equal weight being resolved for the C at...

pidemic drug clofibrate (ethyl-a-p-chlorophenoxyisobutyr ate) in lowering serum lipid levels in experimental animals (49) but it did not enter into clinical trials, possibly due to suspected hepatotoxicity in experimental animals. Previous work by Reddy and Knishnakantha (31) showed that Wy 14,643 caused a significant hepatomegaly and produced a marked increase in the hepatic peroxisome populat...