We investigated the effect of deoxycorticosterone-salt hypertension and its reversal on nuclear ploidy in rat aortic smooth muscle cells, using flow cytometry. Systolic blood pressure and the percentage of cells with tetraploid nuclei increased over a 4-week period and then remained constant. In control rats 6.0 +/- 0.6% of aortic cells had tetraploid nuclei, and this increased to 27.0 +/- 1.1 ...

This article presents clinical data which suggest that the current dosage of losartan 50 to 100 mg/day may not be the optimum in many cases, especially if used as monotherapy in the treatment of proteinuria and we may have to increase to 200 mg/day. However, about 30% of patients cannot take angiotensin-converting enzyme inhibitor (ACEI) because of the side effect of cough. To potentiate the an...

Sharon Bio-Medicine Ltd, Plot L6, Taloja-MIDC, TalukaPanvel, Dist Raigad410 208, Maharashtra, India Shri Jagdishprasad Jhabarmal Tibrewala University, Vidya Nagari, Churu-Bishau Road, Chudela, Dist. Jhunjhunu333 001, Rajasthan, India ABSTRACT A simple, precise and stability-indicating HPLC method was developed and validated for the simultaneous determination of anti-hypertensive drugs Irbesarta...

iatrogenic Jaundice "This is largely synonymous with drug jaundice. Drugs can produce jaundice in two ^ays. Firstly they can produce haemolysis and so overload a normal liver. Secondly they may produce actual liver disease, either by obstructing the intrahepatic biliary Canaliculi or by injuring the liver cells. In the second group obstructive jaundice is Produced by drugs such as methyl testos...

Fibroblast growth factor-23 (FGF23) is a bone-derived hormone regulating renal phosphate reabsorption and vitamin D synthesis in renal proximal tubules. Here, we show that FGF23 directly regulates the membrane abundance of the Na(+):Cl(-) co-transporter NCC in distal renal tubules by a signaling mechanism involving the FGF receptor/αKlotho complex, extracellular signal-regulated kinase 1/2 (ERK...

Experiments were performed in anesthetized 18-19-week-old spontaneously hypertensive rats (SHR) to evaluate the effects of delayed antihypertensive treatment on cerebrovascular function. Animals were treated for 25 +/- 1 days with an oral antihypertensive regimen consisting of hydralazine, reserpine, and chlorothiazide, resulting in normotension within 2 weeks. Cerebral arterioles were examined...

In our study of adolescents with sustained hypertension, single-agent therapy with clonidine significantly reduced blood pressure and heart rate, while hydrochlorothiazide as a single agent significantly reduced only systolic pressure. After 24 weeks of therapy, 40 percent of the diuretic-treated group achieved the treatment goals vs 87 percent in the group treated with clonidine. No alteration...

PRIOR TO the advent of potent oral diuretics, pareliteral mercurial drugs were the mainstays of diuretic therapy. In the search for orally effective diuretic agents, several events stand out. In 1949, Schwartz1 reported the diuretic effect of sulfanilamide in patients with congestive heart failure. In 1953, acetazolamide, a sulfonamide derivative and a potent carbonic anhydrase inhibitor, becam...