2014 Chronic hand eczema (CHE), an inflammatory skin disease, places heavy psychosocial and economic burden on the affected individual and society as a whole. Patch testing is recommended to identify potential causative allergens in each patient. Efficacy of traditional topical treatments render the management of CHE challenging. Oral alitretinoin (9-cis-retinoic acid) is a new drug for the tre...

Cholinesterases (ChE) acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are capable for hydrolyzing esters. Our previous structure-activity analysis of ChE substrates showed that extended conformation of substrate choline moiety is productive for hydrolysis by AChE and its semi-folded conformation is productive for hydrolysis by BChE. The formation of activated complex between ChE an...

PURPOSE To introduce the concept and use of an occlusal-based "orthognathic positioning system" (OPS) to be used during orthognathic surgery. MATERIALS AND METHODS The OPS consists of intraoperative occlusal-based devices that transfer virtual surgical planning to the operating field for repositioning of the osteotomized dentoskeletal segments. The system uses detachable guides connected to a...

Objective- This study examined the effect of Crataegus hydroalcoholic extract (CHE) on intestinal ischemia-reperfusion (I/R) in rats. Design- Experimental study Animals- 25 adult male Wistar rats Procedures- Rats weighing 200±25 g were randomly divided into five individual groups as follows: sham group without...

BACKGROUND This study considers the factors that affect service provision for individuals who present to out-of-hours (OOH) primary care services in the Republic of Ireland and Northern Ireland. The organisations under consideration are known as OOH co-ops. Specifically, an individual can potentially receive one of four services: nurse advice, doctor advice, a treatment centre consultation or a...

The objective of this study was to investigate the effects of different species of oil palm shell (OPS) coarse aggregates on the properties of high strength lightweight concrete (HSLWC). Original and crushed OPS coarse aggregates of different species and age categories were investigated in this study. The research focused on two OPS species (dura and tenera), in which the coarse aggregates were...

Previous research indicates that work modifications can effectively enhance return to work (RTW) at an early stage of work disability. We aimed to examine how occupational physicians (OPs) reason about recommending early return to work (RTW) with work modifications. Pre-defined propositions regarding the use of work modifications in promoting early RTW were discussed in four focus groups with a...

BACKGROUND Occupational diseases are under reported. Targeted education of occupational physicians (OPs) may improve their rate of reporting occupational diseases. AIM To study the effectiveness of an active multifaceted workshop aimed at improving OPs' reporting of occupational diseases. METHODS We undertook a comparative study with 112 OPs in the intervention group and 571 OPs as comparis...

Generally nonchemotactic mutants of Escherichia coli and Salmonella typhimurium were analyzed by interspecies complementation tests to determine the functional correspondence between the che genes of these two organisms. The E. coli che region was introduced into Salmonella recipients by means of a series of F-prime elements. Wild-type che genes of E. coli F'420 complemented all che mutants of ...

Small molecule cholinesterase (ChE) inhibitors represent one of themost effective therapeutic strategies for the treatment of Alzheimer's disease (AD). However, only three of these drugs have entered the market. Understanding of the structures of successful ChE inhibitors is still very limited; therefore, it is an urgent task to identify new scaffolds for the design of ChE inhibitors. In the pr...