نتایج جستجو برای: caspase 7

تعداد نتایج: 675164  

Journal: :Anticancer Research 2021

Background/Aim: We investigated the cytotoxic effects of plumbagin on metastatic retinoblastoma, using highly cell line Y79. Materials and Methods: Effect growth was assessed with water-soluble tetrazolium 1 (WST-1) proliferation assay automated hemocytometry trypan blue-exclusion assay. Cell death studied acridine orange/ethidium bromide live-dead annexin-V-fluorescein isothiocyanate/propidium...

2015
Ri Cui Taewan Kim Matteo Fassan Wei Meng Hui-Lung Sun Young-Jun Jeon Caterina Vicentini Esmerina Tili Yong Peng Aldo Scarpa Guang Liang Yong Kui Zhang Arnab Chakravarti Carlo M. Croce

We recently reported that miR-224 was significantly up-regulated in non-small cell lung cancer (NSCLC) tissues, in particular in resected NSCLC metastasis. We further demonstrated that miR-224 functions as an oncogene in NSCLC by directly targeting TNFAIP1 and SMAD4. However, the biological functions of miR-224 in NSCLC are controversial and underlying mechanisms of miR-224 in the progression a...

2014
Reena Mehta Margaret Scheffler Lorena Tapia Letisha Aideyan Kirtida D Patel Alan M Jewell Vasanthi Avadhanula Minghua Mei Roberto P Garofalo Pedro A Piedra

BACKGROUND Bronchiolitis is the leading cause of hospitalization in infants. Biomarkers of disease severity might help in clinical management. OBJECTIVE To determine the clinical predictiveness of NW-LDH, NW-caspase 3/7, and NW-LDH/NW-caspase 3/7 ratio in bronchiolitis. METHODS Previously healthy children less than 24 months of age with bronchiolitis were recruited from the Texas Children's...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2008
Alexander H Stegh Santosh Kesari John E Mahoney Harry T Jenq Kristin L Forloney Alexei Protopopov David N Louis Lynda Chin Ronald A DePinho

Glioblastoma multiforme (GBM) is a highly aggressive brain cancer that is characterized by the paradoxical features of intense apoptosis resistance yet a marked propensity to undergo necrosis. Bcl2L12 (for Bcl2-Like12) is a nuclear and cytoplasmic oncoprotein that is universally overexpressed in primary GBM and functions to block postmitochondrial apoptosis signaling by neutralizing effector ca...

Journal: :Mutagenesis 2005
Ilse Decordier Enrico Cundari Micheline Kirsch-Volders

Aneugenic and clastogenic agents are good inducers of both micronuclei and apoptosis. In its turn, apoptosis may modify the threshold values for the induction of micronuclei. This is of major concern for accurate assessment of hazard related to exposure to mutagens. In the present work we studied the influence of caspases, the key regulators of the apoptotic process, on the induction of micronu...

Journal: :The Journal of biological chemistry 1998
D Tang V J Kidd

Apoptosis involves the proteolysis of specific cellular proteins by a group of cysteine proteases known as caspases. Many of these cellular targets are either functionally inactivated (e.g. poly(ADP-ribose) polymerase) or activated (e.g. other caspases, gelsolin) by such processing, thereby facilitating the cell death process. Caspase 3 is involved in the processing of many of these proteins. R...

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