Mathematical demography has flowered in many different gardens during the past twenty years. Several reviews of mathematical demograph are available: Keyfitz (1 968), Feishtinger (1 971), Pollard (1 973), Ludwig 8978). Keiding (1975), Menken (1977), Smith and Keyfitz (1977), Kurtz (1981), and Cohen (1984). This necessarily brief review deals only with stochastic models for population projection...

Bizans İmparatoru II. Nikephoros Phokas’ın (963-969) hükümranlığının son döneminde Bulgarlara karşı Kiev Knez’i Svyatoslav (945-972) ile işbirliğine girmesi üzerine Bulgaristan’ı ilhak eden Ruslar, Bizans’ı tehdit edecek bir konuma gelmiş bulunmaktaydı. Knezi Oleg (879-913) hâkimiyet alanını Güney Avrupa içlerinden Karadeniz kıyılarına kadar genişleten etki Balkanlar’a yayarak nihayetinde komşu...

The aim of our study was to develop a liposomal carrier system for the local treatment of bacterial vaginosis, capable to efficiently deliver entrapped drug during an extended period of time. Chloramphenicol was entrapped in liposomes composed of egg phosphatidylcholine/egg phosphatidylgycerol-sodium (9:1, molar ratio) and prepared by two different methods, the proliposome method and the polyol...

PURPOSE The purpose of this study was to develop and evaluate metronidazole loaded floating-mucoadhesive microsphere for sustained drug release at the gastric mucosa. METHODS Alginate gastroretentive microspheres containing metronidazole were prepared by ionic gelation method using sodium bicarbonate as gas forming agent, guar gum as mucoadhesive polymer, and Eudragit L100 as drug release mod...

The present study outlines a systematic approach for designing and development of Ofloxacin floating tablets to enhance the bioavailability and therapeutic efficacy of the drug. Floating tablets of Ofloxacin have shown controlled release thereby proper duration of action at a particular site and are designed to prolong the gastric residence time after oral administration. Floating tablets of Of...

The objective of this work was to develop an oral mucosal drug delivery system to facilitate the local and systemic delivery of acyclovir for the treatment of oral herpes infection caused by the herpes simplex virus (HSV). An in situ gelling system was used to increase the residence time and thus the bioavailability of acyclovir in oral mucosa. Temperature and pH trigged in situ gel formulation...

Article history: Received on: 12/10/2012 Revised on: 27/10/2012 Accepted on: 03/11/2012 Available online: 29/11/2012 Mini matrices containing Losartan potassium as a model drug were prepared by extrusion method using Hydroxy propyl methyl cellulose as matrix materials with or without xanthan gum and carbopol, and combination of xanthan gum and carbopol and propylene glycol as plasticizer. The p...

Chewable modified release tablets containing two active ingredients vitamin C (200mg) and Sodium Fluoride (2mg) were formulated for the treatment of dental diseases. Other ingredients include Mannitol, Carbopol and Hydroxyl-Propyl Methylcellulose (HPMC), in different ratios. These tablets were prepared by direct mixing of Hydroxypropyl Methylcellulose (HPMC), vitamin C, Sodium Fluoride, Carbopo...

PURPOSE A niosome based transdermal drug delivery system of Nimesulide (NIM) was developed and extensively characterized and evaluated for in-vitro performance followed by in-vivo evaluation in rats by carrageenan induced rat paw edema method. METHOD Niosomes were prepared by lipid film hydration technique using tweens and spans. Preparation of niosomes was optimized for highest percent drug ...

Wound healing is a complex process that necessitates organization of different cell types and several signalling molecules. The aim of this study is to evaluate the effect of different concentrations of sildenafil citrate, which decreases cGMP degradation, on wound healing by secondary intention.This study was performed using 25 Sprague Dawley rats weighing 200-250 grams. 4 dorsal defects were ...