background: in some disorders such as diabetes mellitus patients can display depressive symptoms. metformin is among the first-line treatments for management of the type 2 diabetes mellitus which may have some anti-depressant effect. objective: current investigation was performed to examine the anti-depressant effects of metformin and the involvement of nitric oxide (no) in this way, in an expe...

introduction acute poisoning by oral ingestion of mixed hazardous materials can lead to multiorgan toxicity and may represent a special challenge in clinical management, in particular if little is known about the effects of the involved agents. this is especially true when industrial chemical substances have been swallowed, as a huge variety of toxic substances must be taken into account. concl...

atrial fibrillation (af) is a commonly encountered arrhythmia in our daily practice. every year a huge bulk of data is published about different management strategies, new antiarrhythmic drugs, anticoagulation protocols and ablation procedures in these patients. in this review article, we discuss different management strategies and new antiarrhythmic drugs as well as those commonly used. we wil...

background vitamin d (vit d) level may change variously in serums of patients undergoing anti-tuberculosis (anti-tb) therapy using antibiotics such as isoniazid and rifampin. objectives the current study aimed to evaluate all components of calcium (ca) regulatory agents in the six- month period of standard anti- tb therapy. patients and methods eight adults whose pulmonary tb had been diagnosed...

introduction thyroid storm is a rare complication of graves' disease that can carry a poor prognosis. in order to prevent major complications, thyroid storm must be quickly identified in patients and treatment must be promptly implemented. medical treatment is usually initiated with antithyroid medications, such as propylthiouracil (ptu), methimazole, and beta-blockers. however, some patients m...

ba ckground: legionella pneumophila is  a  dangerous pathogenic bacterium can cause serious infectious diseases especially in hospitalized immuno-compromised patients. this bacterium is shown to be resistant against different antibiotics. resistance against a wide range of antibiotics is usually mediated by efflux pump in bacteria. efflux pumps are proteinaceous transporters localized in the cy...

background medication is one of the supplementary steps in dental treatment. dentists prescribe medicine in order to avoid post-surgery complications. to the best knowledge of the researchers, no thorough study has been carried out to review the prescribed drugs in fars province, iran. objectives the current study aimed to determine the current status of the issue and compare it with global sta...

In a guinea pig model of allergic asthma, we investigated the effects of the selective phosphodiesterase inhibitors rolipram (phosphodiesterase 4-selective), Org 9935 (phosphodiesterase 3-selective) and Org 20241 (dual phosphodiesterase 4/phosphodiesterase 3-selective), administered by aerosol inhalation in approximately equipotent bronchodilatory doses, on allergen-induced early and late asthm...