OBJECTIVES We sought to determine the survival experiences of patients bridged to heart transplantation with either intravenous (IV) inotropes or an implantable left ventricular assist device (LVAD). BACKGROUND Because of the operative risks of LVAD implantation and the reported lower mortality associated with inotropic therapy, bridging to heart transplantation with inotropes is thought to b...

The nonenzymatic copying of RNA templates with imidazole-activated nucleotides is a well-studied model for the emergence of RNA self-replication during the origin of life. We have recently discovered that this reaction can proceed through the formation of an imidazolium-bridged dinucleotide intermediate that reacts rapidly with the primer. To gain insight into the relationship between the struc...

Clusters, Vinylidene Ligands. Alkylidyne Ligands Based on the observation that the alkylidyne bridged cluster HFeCo2(CO)4(/<3-C —CH 3) spon­ taneously loses H ; to form the vinylidene bridged cluster FeCo2(CO)y(«3-C—CH :). the intercon­ versions between these types of ligands on mixed trinuclear clusters were investigated. It was found that in all cases clusters of the type HM3(/<3-C -C H 2R) c...

The reliability of the radiological assessment of the healing of tibial fractures remains undetermined. We examined the inter- and intraobserver agreement of the healing of such fractures among four orthopaedic trauma surgeons who, on two separate occasions eight weeks apart, independently assessed the radiographs of 30 patients with fractures of the tibial shaft which had been treated by intra...

By the reaction of chiral Mn(III) Schiff-base complexes with the dicyanoruthenate building block, [Ru(salen)(CN)2](-) (salen(2-) = N,N'-ethylenebis(salicylideneimine) dianion), two couples of enantiomerically pure chiral cyano-bridged heterobimetallic one-dimensional (1D) chain complexes, [Mn((R,R)-salcy)Ru(salen)(CN)2]n (1-(RR)) and [Mn((S,S)-salcy)Ru(salen)(CN)2]n (1-(SS)) (Salcy = N,N'-(1,2-...

A series of novel PtII-linked double helices were prepared by inter- or intrastrand ligand-exchange reactions of the complementary duplexes composed of chiral or achiral amidine dimer and achiral carboxylic acid dimer strands joined by trans-PtII-acetylide complexes with PPh3 ligands using chiral and achiral chelating diphosphines. The structure and stability of the PtII-linked double helices w...

A set of fluorophenyl-substituted adt-bridged Fe2S2 active site models of Fe-only hydrogenase, [(micro-SCH2)2NR]Fe2(CO)6 (, R=C6F4CF3-p; , R=C6H4CF3-p) and [(micro-SCH2)2NR]Fe2(CO)5(PPh3) (, R=C6F4CF3-p; , R=C6H4CF3-p), have been synthesized and well characterized. Spectroscopic and electrochemical studies demonstrate that the aryl-substituted complexes are stable toward a strong acid HBF4/Et2O...

Diruthenium( ii , iii ) paddlewheel carboxylates combine the pharmacological properties of dimetallic center with those ascribed to μ-bridged carboxylates, thus leading novel, dual-acting anticancer metallodrugs.

Porphyrin-fluorene conjugates bridged by ethynylene were synthesized through Pd-catalyzed cross-coupling reaction. These molecules showed strong nonlinear absorption when measured using a nanosecond Z-scan method. The largest effective two-photon absorption cross-section was observed for trisporphyrin as 2.7 × 105 GM at 760 nm, which was 10 times larger than that obtained for monoporphyrin. INT...

Rare examples of phenoxido-bridged Fe III –Ln binuclear complexes are synthesized, and their dynamic static magnetic properties rationalized by ab initio calculations.