Background: This study aimed to evaluate the performance of machine learning algorithms using lactate and arterial blood gas parameters predict imminent risk death in extremely low birth weight infants. Methods: A retrospective cohort analyzing preterm infants with less than 1000 grams a single-center tertiary neonatal intensive ca...

conclusions ia fluid resuscitation is superior to iv resuscitation in hemorrhagic shock induced cardiac arrest. results while iv rl infusion failed to restore chest motion in mice (n = 5), ia rl infusion restored chest motion in all mice examined (n = 6) (p = 0.0067). in three mice, iv rl infusion after cardiac arrest showed no effect on cc. after failure of venous infusion, ia rl infusion was ...

We studied the central hemodynamic, leg blood flow, and metabolic responses to maximal upright bicycle exercise in 30 patients with chronic heart failure attributable to severe left ventricular dysfunction (ejection fraction, 24+8%) and in 12 normal subjects. At peak exercise, patients demonstrated reduced oxygen consumption (15.1±+4.8 vs. 32.1±9.9 ml/kg/min, p <0.001), cardiac output (8.7±3.2 ...

BACKGROUND Gut ischaemia may contribute to morbidity in patients after cardiopulmonary bypass (CPB), but little is known about the metabolic state of the large bowel in such patients. Therefore we estimated the concentrations of L-lactate and Pco(2) in rectal mucosa in patients undergoing cardiac surgery with or without the use of CPB. METHODS Patients undergoing coronary artery bypass grafti...

Hyperbaric oxygen therapy (HBOT) or intravenous hydroxocobalamin (OHCob) both abolish cyanide (CN)-induced surges in interstitial brain lactate and glucose concentrations. HBOT has been shown to induce a delayed increase in whole blood CN concentrations, whereas OHCob may act as an intravascular CN scavenger. Additionally, HBOT may prevent respiratory distress and restore blood pressure during ...

PURPOSE To characterize the different components of metabolic acidosis in patients with hyperlactatemia in order to determine the degree to which lactate is responsible for the acidosis and the relevance that this might have in the outcome of these patients. METHODS Arterial blood gas, arterial lactate, Na+, K+, Ca2+, Mg2+, Cl-, phosphate, albumin, and creatinine were measured on admission to...

BACKGROUND Persistent hyperlactatemia during septic shock is multifactorial. Hypoperfusion-related anaerobic production and adrenergic-driven aerobic generation together with impaired lactate clearance have been implicated. An excessive adrenergic response could contribute to persistent hyperlactatemia and adrenergic modulation might be beneficial. We assessed the effects of dexmedetomidine and...

Exhaustive exercise induced a severe short-lived (0-1 h) respiratory, and longer-lived (0-4 h) metabolic, acidosis in the extracellular fluid of the rainbow trout. Blood 'lactate' load exceeded blood 'metabolic acid' load from 1-12 h after exercise. Over-compensation occurred, so that by 8-12 h, metabolic alkalosis prevailed, but by 24 h, resting acid-base status had been restored. Acid-base ch...

the purpose of this study was to investigate the potential responses of the cardiovascular system and regional blood flow to hypoxic hypoxia (bb) and to carbon monoxide (co)-induced hypoxia (coh). ten anesthetized cats were studied under two nonnoxic (control: cont) and two hypoxic conditions. four types of radioactive micro spheres were used to measure regional blood flow during cont and two h...

Blood-brain barrier permeability to L-lactate was studied in 18 patients with the double indicator technique. Venous outflow curves were obtained during normo- and hypercapnia and were analyzed by means of a model that takes tracer backflux and capillary heterogeneity of transit times into account. The average unidirectional extraction of L-lactate was 15%; the transport from the blood to the b...