Wild bitter gourd (Momordica charantia L. var. abbreviate Seringe), a common vegetable in Asia, is used in traditional medicine to treat various diseases, including inflammation. Extant literature indicates that wild bitter gourds have components that activate PPARα and PPARγ. This research probed the influence of adding wild bitter gourd to diets on inflammation responses in mice with sepsis i...

This work describes the first approach in the development of a comprehensive classification method for bitterness of small molecules. The data set comprises 649 bitter and 13 530 randomly selected molecules from the MDL Drug Data Repository (MDDR) which are analyzed by circular fingerprints (MOLPRINT 2D) and information-gain feature selection. The feature selection proposes substructural featur...

While bitter manioc has been one of the most important staple crops in the central Amazon for thousands of years, there have been few studies of its cultivation in the fertile whitewater landscapes of this region. Anthropological research on bitter manioc cultivation in the Amazon has focused almost exclusively on long-fallow shifting cultivation in marginal upland areas of low soil fertility. ...

Mapping of the chromosomal location of genes essential for sweet and bitter taste and identification of the relevant G protein-coupled receptors reveals unanticipated complexity in taste signaling pathways. The distribution of sweet and bitter receptors suggests complete cellular segregation of these taste modalities. Sweet compounds may be distinguished through differential expression of sweet...

1 2 3 Sweet-Bitter and Umami-Bitter Taste Interactions in Single 4 Parabrachial Neurons in C57BL/6J Mice 5 6 Kenichi Tokita and John D. Boughter Jr 7 8 Department of Anatomy and Neurobiology 9 University of Tennessee Health Science Center 10 855 Monroe Avenue, Suite 515, Memphis, TN 38163, USA 11 12 13 14 15 16 17 Running head: Sweetand umami-bitter taste interactions in the mouse PbN 18

Citrus aurantium L. (Rutaceae), commonly known as bitter orange, has multiple therapeutic potentials. An experimental qualitative study was carried out with the objective of knowing characteristics consumption C. (CA) in Tabasco population. To validate its use, an ethanolic extract (85 %) prepared from dry CA leaves and phytochemical screening performed, subsequent quantification content total ...

We sought to define the gustatory neural representation in primates for stimuli that humans describe as predominantly bitter. Thus we analyzed the responses of single neurons from the insular cortex of two alert, male cynomolgus macaques in response to the oral application of four basic taste stimuli (glucose, NaCl, HCl, and quinine HCl) and fruit juice, and to a series of 15 other chemicals to...

Bitter taste receptors (TAS2Rs or T2Rs) belong to the superfamily of seven-transmembrane G protein-coupled receptors, which are the targets of >50% of drugs currently on the market. Canonically, T2Rs are located in taste buds of the tongue, where they initiate bitter taste perception. However, accumulating evidence indicates that T2Rs are widely expressed throughout the body and mediate diverse...

Taste receptor cells use multiple signaling mechanisms to detect different taste stimuli in the oral cavity. Ionic stimuli (sour, salty) interact directly with ion channels to elicit responses, whereas bitter, sweet, and umami tastants activate G protein-coupled receptors to initiate phospholipase C (PLC)-dependent release of calcium from intracellular stores. However, the precise role for PLC ...

Cassava roots are used as human food in many processed forms and products. Fermentation is the initial step needed in the development of various flavour precursors in the cassava and generally conducted as traditional, indigenous processes leading sometimes to the undesirable quality of final products depending probably on the variety (bitter or sweet) of cassava. Both sweet and bitter varietie...