Objectives The purpose of this study was the automated generation and validation of parametric blood flow velocity maps, based on contrast-enhanced ultrasound (CEUS) scans. Materials and Methods Ethical approval for animal experiments was obtained. CEUS destruction-replenishment sequences were recorded in phantoms and three different tumor xenograft mouse models. Systematic pixel binning and ...

Oligonucleotide signatures, especially tetranucleotide signatures, have been used as method for homology binning by exploiting an organism's inherent biases towards the use of specific oligonucleotide words. Tetranucleotide signatures have been especially useful in environmental metagenomics samples as many of these samples contain organisms from poorly classified phyla which cannot be easily i...

The problem of mismatched decoding for discrete memoryless channels is addressed. A mismatched cognitive multiple-access channel is introduced, and an inner bound on its capacity region is derived using two alternative encoding methods: superposition coding and random binning. The inner bounds are derived by analyzing the average error probability of the code ensemble for both methods and by a ...

Metagenomics has become an integral part of defining microbial diversity in various environments. Many ecosystems have characteristically low biomass and few cultured representatives. Linking potential metabolisms to phylogeny in environmental microorganisms is important for interpreting microbial community functions and the impacts these communities have on geochemical cycles. However, with me...

Positive-definite kernel functions are fundamental elements of kernel methods and Gaussian processes. A well-known construction of such functions comes from Bochner’s characterization, which connects a positive-definite function with a probability distribution. Another construction, which appears to have attracted less attention, is Polya’s criterion that characterizes a subset of these functio...