Local drug delivery depots have significant clinical utility, but there is currently no noninvasive technique to refill these systems once their payload is exhausted. Inspired by the ability of nanotherapeutics to target specific tissues, we hypothesized that blood-borne drug payloads could be modified to home to and refill hydrogel drug delivery systems. To address this possibility, hydrogels ...

The purpose of this research was to develop and evaluate multiparticulates of alginate and chitosan hydrogel beads exploiting pH sensitive property for colon-targeted delivery of theophylline. Alginate and chitosan beads were prepared by ionotropic gelation method followed by enteric coating with Eudragit S100. All formulations were evaluated for particle size, encapsulation efficiency, swellab...

Alginate gel crosslinked by calcium ions (Ca(2+)) has been widely used in cartilage tissue engineering. However, most studies have been largely performed in vitro in medium with a calcium concentration ([Ca(2+)]) of 1.8mM, while the calcium level in the synovial fluid of the human knee joints, for example, has been reported to be 4mM or even higher. To simulate the synovial environment, the two...

Abstract Despite the impressive performance of recent marine robots, many their components are non‐biodegradable or even toxic and may negatively impact sensitive ecosystems. To overcome these limitations, biologically‐sourced hydrogels a candidate material for robotics. Recent advances in embedded 3D printing have expanded design freedom hydrogel additive manufacturing. However, small‐scale hy...

In this study, a novel pH/temperature sensitive hydrogel bead with core-shelled structure, composed of calcium alginate (Ca-alginate) and poly(N-acryloylglycine) (PAG), was prepared using as a drug delivery system. The equilibrium swelling has indicated the distinct sensitivities of the beads to pH value and temperature. In pH = 7.4 phosphate buffer solution (PBS), the cumulative release amount...

This paper reports a simple, rapid, and sugar-selective method to induce gelation from glucose-containing samples. This method employs glucose oxidase (GOx) to selectively "recognize" and oxidize glucose to generate gluconic acid, which acts to solubilize calcium carbonate and release calcium ions. The release of calcium ions triggers gelation of the calcium-responsive polysaccharide alginate t...

Hydrogel wound dressing makes easier the treatment of patients suffering from difficult wounds. A new process for manufacturing a sterile, packaged hydrogel dressing, based on an interpenetrating structure calcium alginate, agar, and polyvinylpyrrolidone, was recently developed. The formulation overtakes some previous technologies’ drawbacks expressing better resistance to mechanical deformatio...

Abstract Introduction In bioprinting, it is essential to correctly characterise the materials be used in order ensure highest cell viability while maintaining best structural properties of hydrogels. Methods Alginate-based hydrogels with different concentrations have been characterised because they are currently ones printing according literature. The chosen were 3.5%, 4% and 5% alginate, then ...

We hypothesized that local delivery of GDNF in spinal cord lesion via an injectable alginate hydrogel gelifying in situ would support spinal cord plasticity and functional recovery. The GDNF release from the hydrogel was slowed by GDNF encapsulation in microspheres compared to non-formulated GDNF (free GDNF). When injected in a rat spinal cord hemisection model, more neurofilaments were observe...

Background Controlled drug delivery system is highly important for not only prolonged the efficacy of drug but also cellular development for tissue engineering. A number of biopolymer composites and nanostructured carriers behave been used for the controlled drug delivery of therapeutics. Recently, in vitro microfluidic devices that mimic the human body have been developed for drug-delivery app...