background: in recent years, immunocompromised patients are at high risk for the development of invasive aspergillosis. due to the increase of antimicrobial resistance, natural agents with medicinal and immunomodulatory effects has gained more attention. honey is a natural substance with documented antimicrobial, anti-inflamatory and wound healing effects. objectives: the purpose of this study ...

Inbred strains of mice were infected intraperitoneally with Coccidioides immitis, and the mean lethal dose was determined after 28 days. DBA/2N mice had a mean lethal dose of greater than 10(5) arthroconidia, whereas BALB/cAnN, C57BL/6N, and C57L/J mice had a mean lethal dose of less than or equal to 10(3). Since both BALB/c and DBA/2 mice are the H-2d haplotype, resistance is not primarily det...

The susceptibility of several strains of inbred mice to infection with the filarial worm Brugia pahangi has been examined. BALB/C, C57BL/10, C3H/He, 101, CBA/Ca mice, congenitally asplenic (DH/+) mice and their normal litter-mates (+/+) were each challenged by the intraperitoneal inoculation of 50 infective larvae. During the first four weeks of infection high (19-42%) larval recoveries were ob...

The difference in the timing of the regeneration process of skeletal muscle between SJL/J and BALB/c mice was investigated using grafts of whole skeletal muscle (both autografts and allografts). Histological, autoradiographic and immunohistochemical techniques were used in the investigation. Infiltration of leucocytes into autografts, numbers of desmin-positive myogenic cells and myotube format...

T regulatory cells (CD4(+)CD25(+)) play an important role in the regulation of the immune response. However, little is known about the ability of T regulatory cells to regulate endothelial cell (EC) damage following activation of lymphocytes with IL-2. Therefore, in the current study, we examined the role of T regulatory cells and the subsequent T(h)1/T(h)2 bias in IL-2-mediated EC injury using...

Touchscreen technology is increasingly being used to characterize cognitive performance in rodent models of neuropsychiatric disorders. Researchers are attracted to the automated system and translational potential for touchscreen-based tasks. However, training time is extensive and some mouse strains have struggled to learn touchscreen tasks. Here we compared the performance of commonly used C5...

objective(s): the adverse effects of pyridaben on reproductive system in male animals are not well established. this study was designed to elucidate how pyridaben can effects the histomorphometric, hormonal alternations and reproductive functions of balb/c mice .   materials and methods : for this study, 80 adult and apparently healthy male balb/c mice were divided into three groups viz, contro...

Genetic restrictions in generation and expression of hapten-specific suppressor cells for contact sensitivity were found. Dinitrophenol- (DNP) or trinitrophenol-modified mouse spleen cells (SC) induced suppressors in donors able to transfer suppression to normal recipients. When allogeneic DNP-SC were injected into BALB/c mice, cells were generated which were suppressive only in the allogeneic ...

Background: Leishmania is a pathogenic parasite which infects mononuclear cells in vertebrate hosts. Different strategies have been taken to develop immunity against Leishmania . DCs loaded with immunogenic antigen have resulted in different levels of Th1-type immune response and cytotoxic T lymphocytes (CTL) activity. Objective: To evaluate the potency of DCs primed with soluble Leishmania mex...

objective: leishmaniasis is one of the most important parasitic infectious diseases in the world. since last century, many efforts have been made to control and treat the disease, but appropriate vaccines, pesticides and medicines are not available or even eligible. the purpose of this study was to evaluate the effect of hydro-alcoholic extract of seidlitzia rosmarinus on the lesions of experim...