نتایج جستجو برای: atf6

تعداد نتایج: 724  

2014
Gilles Crambert Thomas Ernandez Christine Lamouroux Isabelle Roth Eva Dizin Pierre‐Yves Martin Eric Féraille Udo Hasler

Large shifts of osmolality occur in the kidney medulla as part of the urine concentrating mechanism. Hyperosmotic stress profoundly challenges cellular homeostasis and induces endoplasmic reticulum (ER) stress. Here, we examined the unfolded protein response (UPR) in hyperosmotically-challenged principal cells of the kidney collecting duct (CD) and show its relevance in controlling epithelial s...

Journal: :The journals of gerontology. Series A, Biological sciences and medical sciences 2015
Liliana Matos Alexandra Monteiro Gouveia Henrique Almeida

The aging process is characterized by progressive accumulation of damaged biomolecules in the endoplasmic reticulum, as result of increased oxidative stress accompanying cellular senescence. In agreement, we hypothesized that WI-38 human cellular models of replicative senescence and stress-induced premature senescence (SIPS) induced by hydrogen peroxide (H2O2-SIPS) or copper sulfate (CuSO4-SIPS...

2016
Hongrui Guo Hengmin Cui Jing Fang Zhicai Zuo Junliang Deng Xun Wang Ling Zhao Kejie Chen Jie Deng

Up to now, the precise mechanism of Ni toxicology is still indistinct. Our aim was to test the apoptosis, cell cycle arrest and inflammatory response mechanism induced by NiCl2 in the liver of broiler chickens. NiCl2 significantly increased hepatic apoptosis. NiCl2 activated mitochondria-mediated apoptotic pathway by decreasing Bcl-2, Bcl-xL, Mcl-1, and increasing Bax, Bak, caspase-3, caspase-9...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2016
Wilhelmus J Kwanten Yves-Paul Vandewynckel Wim Martinet Benedicte Y De Winter Peter P Michielsen Viviane O Van Hoof Ann Driessen Jean-Pierre Timmermans Pierre Bedossa Hans Van Vlierberghe Sven M Francque

Autophagy and the unfolded protein response (UPR) are key cellular homeostatic mechanisms and are both involved in liver diseases, including nonalcoholic fatty liver disease (NAFLD). Although increasing but conflicting results link these mechanisms to lipid metabolism, their role and potential cross talk herein have been poorly investigated. Therefore, we assessed the effects of hepatocyte-spec...

2011
Erica L. Cain Sterling E. Braun Alexander Beeser

BACKGROUND Analysis of chromosomal rearrangements within primary tumors has been influential in the identification of novel oncogenes. Identification of the "driver" gene(s) within cancer-derived amplicons is, however, hampered by the fact that most amplicons contain many gene products. Amplification of 1q21-1q23 is strongly associated with liposarcomas and microarray-based comparative genomic ...

2015
Wei Geng Chung-Mau Lo Kevin T.P. Ng Chang-Chun Ling Xiang Qi Chang-Xian Li Yuan Zhai Xiao-Bing Liu Yuen-Yuen Ma Kwan Man

Tumor recurrence remains an obstacle after liver surgery, especially in living donor liver transplantation (LDLT) for patients with hepatocellular carcinoma (HCC). The acute-phase liver graft injury might potentially induce poor response to chemotherapy in recurrent HCC after liver transplantation. We here intended to explore the mechanism and to identify a therapeutic target to overcome such c...

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