Paraoxonase 1 (PON1) hydrolyzes a number of toxic organophosphorous compounds and reduces lipid peroxide accumulation, and PON1 genetic polymorphisms in the coding region modulate serum PON1 activity. In this study, we investigated the association between 3 polymorphisms of PON1 located in intron 5 (17899insdelTT and 17974CT) and exon 6 (192QR) and serum PON1 activity. The genetic polymorphisms...

Introduction: Esterases (E.C. 3.1.1.) are widely distributed in nature and catalyze the hydrolysis of ester bonds. Arylesterases (E.C. 3.1.1.2.) show a preferential substrate specificity for aromatic esters. The mammalian arylesterases play important roles in the detoxification of organophosphorous compounds and are used as diagnostic indicators for liver cirrhosis. Very little is known about t...

Bladder cancer (BC) is the ninth-most common type of cancer in both genders. Approximately 429,000 cases were reported in 2012, and each year, approximately 165,000 deaths worldwide are attributed to BC. The mortality rate is lower than the incidence rate, and for males, the highest incidence is found in West Asia (8.4 in 100,000) and for females, in North Africa (1.6 in 100,000).[1] The most c...

BACKGROUND Recurrent aphthous stomatitis (RAS) is a chronic relapsing inflammatory disorder of the oral mucosa with unknown etiology. Oxidative stress (OS) is suggested to play a main role in the etiopathogenesis in RAS. OBJECTIVE In this study, we hypothesize that a systemic OS is present in patients with RAS. METHODS Forty-four patients with active RAS lesions and 38 healthy controls were...

Oxidized LDL cholesterol (ox-LDL) is considered to be a key factor of initiating and accelerating coronary heart disease CHD diabetes Mellitus DM , associated with several mechanisms one them Oxidative stress. The aim this study was find the association between ox- ,HDL-C TG LDL-C arylesterase risk in different age groups males females difference these factors can explain sex how much changes l...

INTRODUCTION Poor metabolic control of type 1 diabetes is one of the most important factors accelerating the development of late diabetic complications. Several other factors that might contribute to this process are currently being investigated. Low paraoxonase 1 (PON1) activity and high lipid peroxide (LPO) levels contribute to endothelial damage, but it remains unclear whether they are criti...